・The Potential of Euglena Gracilis for Fundamental Health Enhancement
・Development of Mass Production Technology for New Algae
・Establishment of Genome Editing Techniques in Euglena and Their Commercial Applications
The Project for Integrated sustainable energy and food production from microalgae-based carbon capture and utilization
発表者
鈴木健吾
Joint research destination
理化学研究所、東京大学
2022年11月12日（インドネシア）
Presentation conference
超異分野学会
Research subject
・Evaluation of Tempeh, a fermented soybean food supplemented with microalgae Euglena gracillis
・Demonstration study of bio-jet fuel business model based on cascade utilization of microalgae biomass Fuel Business Model Based on Cascade Utilization of Microalgae Biomass
Research and development on the functionality of components derived from Euglena
発表者
Yu Inaba, Ayaka Nakashima, Ako Murata, Nur Akmalia Hidayati, Chihana Toyokawa, Koji Yamada , Kengo Suzuki
Joint research destination
インドネシア共和国研究革新庁、理化学研究所
2022年9月14～16日（愛知）
Presentation conference
日本マイクログラビティ応用学会
Research subject
微細藻類を用いた資源循環型食料生産の実用性検討
発表者
豊川知華、山田康嗣、鈴木健吾
Joint research destination
―
2022年9月5～6日（岡山）
Presentation conference
日本食品工学会
Research subject
微細藻類ユーグレナ由来高機能性多糖パラミロンの造粒条件検討と大量生産
発表者
堀内真展、足立秀行、竹内卓人、中島綾香
Joint research destination
八重山殖産
2022年8月27日（大阪）
Presentation conference
超異分野学会
Research subject
・微細藻類Euglena gracilis由来多糖「パラミロン」の商用スケール精製
・小型宇宙生物実験モジュールの開発
・麴による抗酸化物質エルゴチオネイン生産 ～ユーグレナの発酵助剤としての可能性～
・新規藻類の大量培養技術の開発
・放棄耕作地を用いた低コストでオフグリッドな藻類培養レースウェイの開発
・ミドリムシと未利用資源を用いた低魚粉飼料の開発
・Metagenomics of the fermented Euglena gracilis reveals key regulators of volatile and non-volatile amine accumulation and their relation to algal product quality and quantity
・ユーグレナの活動音を音源化した楽曲「ミドリムシのうた」の発表
・Development of endogenous promoters driving high-level expression of introduced genes in the model diatom Phaeodactylum tricornutum
・A modified single-cell electroporation method for molecule delivary into a motile protist, Euglena gracilis.
Biological Engineering Society Kyushu Branch Meeting
Research subject
Analysis of useful lipids contained in Euglena
発表者
Ayaka Nakajima, etc.
Joint research destination
Saga University
December 6-9, 2017 (Kobe)
Presentation conference
Molecular Biology Society
Research subject
MicroRNA-141 and microRNA-200a regulates α-MSH-stimulated melanogenesis on murine B16-4A5 melanoma cells.
発表者
Ayaka Nakajima, Kengo Suzuki, etc.
Joint research destination
Mie University
November 18, 2017 (Osaka)
Presentation conference
Nutrition and Food Society Kansai Branch Meeting
Research subject
Anti-influenza virus substances contained in Kalahari watermelon and inhibition mechanism
発表者
Ayaka Nakajima, Kengo Suzuki, etc.
Joint research destination
Mukogawa Women's University
November 18, 2017 (Osaka)
Presentation conference
Nutrition and Food Society Kansai Branch Meeting
Research subject
Anti-influenza effect of Kalahari watermelon-derived ingredients in vivo and in vitro
発表者
Ayaka Nakajima, Kengo Suzuki, etc.
Joint research destination
Mukogawa Women's University
September 20-22, 2017 (Nagoya)
Presentation conference
Chemical Engineering Society
Research subject
Euglena to hydrocarbon fuel by catalytic cracking
発表者
Takuya Matsumoto, Haruhisa Ota
Joint research destination
Shinshu University
September 20-22, 2017 (Nagoya)
Presentation conference
Chemical Engineering Society
Research subject
Deoxygenation of guaiacol using hydrogen transfer reaction in catalytic cracking
発表者
Takuya Matsumoto, Haruhisa Ota
Joint research destination
Shinshu University
September 16-17, 2017 (Kyoto)
Presentation conference
Carotenoid research discussion
Research subject
Euglena derived carotenoids to chicken eggs
発表者
Shota Watanabe, Kengo Suzuki, etc.
Joint research destination
Asuka Animal Health Co., Ltd.
September 7-9, 2017 (Tokyo)
Presentation conference
Agricultural Food Engineering Society
Research subject
Basic research on the utilization Euglena the agricultural field
発表者
Shota Watanabe, Ryohei Nakano, Kengo Suzuki, etc.
Joint research destination
Kitasato University
September 11-14, 2017 (Tokyo)
Presentation conference
Bioengineering Society
Research subject
Strengthening organic acid production in Euglena gracilis
発表者
Osamu Iwata, Ayaka Nakajima, Kengo Suzuki, etc.
Joint research destination
Meiji University
August 26, 2017 (Obihiro)
Presentation conference
Euglena Study Group
Research subject
Strengthening organic acid production in Euglena gracilis
発表者
Osamu Iwata, Ayaka Nakajima, Kengo Suzuki, etc.
Joint research destination
Meiji University
2017年06月15日（兵庫）
Presentation conference
第21回腸内細菌学会
Research subject
ユーグレナ及びその貯蔵多糖パラミロンの摂取による排便及び腸内細菌叢に対する影響の検討
発表者
中島 綾香、澤村 弘美 、虞薈 静、鈴木 健吾、渡邊 敏明
Joint research destination
兵庫県立大学、大阪青山大学
2017年06月10日（ボストン）
Presentation conference
32nd Congress of the International Society for Advancement of Cytometry (CYTO2017)
Research subject
FACS-based selective breeding of Euglena gracilis for efficient biofuel production
発表者
Kengo Suzuki, Ayaka Nakashima, Koji Yamada, Hideyuki Suzuki, Takuto Takeuchi, Yusuke Kazama, Sharbanee Mitra, Tomoko Abe, Osamu Iwata, Keisuke Goda
Joint research destination
東京大学、理化学研究所, カリフォルニア大学
May 19-21, 2017 (Okinawa)
Presentation conference
Japan Society of Nutrition and Food Science
Research subject
Examination of the mechanism of immunoregulation of the stored polysaccharide paramylon of Euglena gracilis
発表者
Ayaka Nakajima, Naoko Oko, Kengo Suzuki, etc.
Joint research destination
University of Tokyo
March 30, 2017 (Kobe)
Presentation conference
Japanese Poultry Society
Research subject
Effect of replacement of soybean meal in feed with Euglena gracilis on chicken chick growth
発表者
Shota Watanabe, Osamu Iwata, Kengo Suzuki, etc.
Joint research destination
Iwate University, Minami Foods Co., Ltd.
March 30, 2017 (Kobe)
Presentation conference
Japanese Poultry Society
Research subject
Effect of addition of Euglena gracilis on the growth and meat quality of Hinai chicken
発表者
Shota Watanabe, Kengo Suzuki, Osamu Iwata, etc.
Joint research destination
Akita Prefectural Livestock Experiment Station
March 27-30, 2017 (Kobe)
Presentation conference
Japanese Society of Animal Science
Research subject
The effect of Euglena supplementation on methane emission (in-vivo)
発表者
Shota Watanabe, Kengo Suzuki, etc.
Joint research destination
Obihiro University of Agriculture and Veterinary Medicine
2017年03月24日（宮城）
Presentation conference
日本薬学会第137年会
Research subject
Euglena extract on adipocyte differentiation
発表者
大湖菜央子、阿閉耕平、三輪由布子、中島綾香、岩田修、鈴木健吾
Joint research destination
―
March 18-20, 2017 (Kyoto)
Presentation conference
Japan Society for Bioscience and Biotechnology
Research subject
Liver fibrosis inhibitory effect of Euglena gracilis Z and stored polysaccharide paramylon
発表者
Ayaka Nakajima, Kengo Suzuki, Nagahisa Nakano, etc.
Joint research destination
―
So far, Euglena intake improves colorectal cancer and blood sugar levels, paramylon intake alleviates the symptoms of atopic dermatitis, and carbon tetrachloride causes hepatitis. In this study, the Euglena and paramylon on NASH and fibrosis were verified using STAM® mice. As a result, it Euglena suppressed liver fibrosis by a route not involved in inflammation, and paramylon may have prevented liver fibrosis by improving inflammation. Suppressing fibrosis, which is a carcinogenic factor from NASH, leads to prevention of liver cancer. Therefore, Euglena and paramylon as foods suppresses fibrosis to cause cancer. May function in the prevention of.
November 7, 2016 (Tokyo)
Presentation conference
Euglena Study Group
Research subject
Liver fibrosis inhibitory effect of Euglena gracilis Z and stored polysaccharide paramylon
発表者
Ayaka Nakajima, Yuka Shirakata, Taishi Hashiguchi, Yoshida main tax, Kengo Suzuki, Nagahisa Nakano
Joint research destination
―
2016年10月7日（大阪）
Presentation conference
第38回日本臨床栄養学会総会
Research subject
カラハリスイカ果汁による 抗インフルエンザウイルス効果
発表者
森本亮祐、曽我部りほ、中島綾香、 鈴木健吾、隅谷栄伸、伊勢川裕二
Joint research destination
武庫川女子大学、公益財団法人東洋食品
June 17, 2016 (Kyoto)
Presentation conference
Japanese Society of Inflammation and Regenerative Medicine
Research subject
Euglena gracilis Z and its sugar storage substance relieve rheumatoid arthritis symptoms
発表者
Ayaka Nakajima, Hiroaki Takimoto, Yuta Asayama, Kengo Suzuki
Joint research destination
Kitasato University
Euglena, paramylon, and amorphous paramylon on rheumatoid arthritis using a mouse collagen-induced arthritis model. Comparing the arthritis scores, which represent the severity of arthritis, all showed significantly lower values compared to the control group.
Rotavirus is a virus that causes infectious gastroenteritis, which is a gastrointestinal disease, and although its vaccine has already been developed, there are ineffective types of vaccines and recombinants with vaccines, so countermeasures against them, etc. Is required. Therefore, in this study, we examined in vitro whether rotavirus growth inhibitory activity was observed in chlorella powder and the like. As a result, growth inhibitory activity was observed in some experimental plots, suggesting that chlorella has rotavirus growth inhibitory activity.
May 14, 2016 (Kobe)
Presentation conference
Japan Society of Nutrition and Food Science
Research subject
Rotavirus growth inhibitory effect of Euglena gracilis Z
発表者
Ayaka Nakajima, Riho Sogabe, Kengo Suzuki, Yuji Isegawa
Joint research destination
Mukogawa Women's University
March 29, 2016 (Yokohama)
Presentation conference
Pharmaceutical Society of Japan
Research subject
Effect of Cellulose Single Nanofibers on Human Skin Fibroblasts
Rotavirus is a virus that causes infectious gastroenteritis, which is a gastrointestinal disease, and although its vaccine has already been developed, there are ineffective types of vaccines and recombinants with vaccines, so countermeasures against them, etc. Is required. Therefore, in this study, we examined in vitro whether rotavirus growth inhibitory activity was observed in chlorella powder and the like. As a result, growth inhibitory activity was observed in some experimental plots, suggesting that chlorella has rotavirus growth inhibitory activity.
So far, it has been reported that ingestion of Euglena (scientific name: Euglena gracilis) may contribute to the improvement of lifestyle-related diseases such as suppression of blood glucose elevation and promotion of cholesterol excretion. In this study, in order to verify the effect of Euglena on obesity, which is one of the lifestyle-related diseases, the effect of Euglena extract on adipocyte differentiation was investigated. The results suggest that the Euglena extract has an inhibitory effect on adipocyte differentiation.
November 7, 2015 (Miyazaki University)
Presentation conference
Euglena Study Group
Research subject
E. gracilis Z and its sugar storage substance alleviate the symptoms of rheumatoid arthritis
発表者
Ayaka Nakajima, Hiroaki Takimoto, Yuta Asayama, Kengo Suzuki
Joint research destination
Kitasato University
Euglena, paramylon, and amorphous paramylon on rheumatoid arthritis using a mouse collagen-induced arthritis model. Comparing the arthritis scores, which represent the severity of arthritis, all showed significantly lower values compared to the control group.
November 7, 2015 (Miyazaki University)
Presentation conference
Euglena Study Group
Research subject
Identification of paramylon-degrading enzyme endo-1,3-β-glucanase and enzymatic functional analysis
β-glucanase is an enzyme that hydrolyzes polysaccharides such as laminarin and curdlan whose main structure is β-1,3-glucan of glucose. It is a feed additive, texture improver, beer filtration efficiency improver, etc. It is an enzyme that is expected to be used in various industries. Exo-type β-1,3-glucanase has been identified from E. gracilis so far, but in recent years, we have newly identified three types of endo-1,3 from E. gracilis lysate using enzyme activity as an index. We have succeeded in purifying and identifying -β-glucanase and further determining the base sequence of the gene encoding this enzyme. In this study, we report the results of enzymatic functional analysis such as metabolic rate parameters (Km, Vmax), substrate specificity, and indicated temperature of this enzyme.
October 31, 2015 (Meiji University)
Presentation conference
Microbial Study Group
Research subject
Industrial use of the microalga Euglena
発表者
Ayaka Nakajima
Joint research destination
―
2014年11月10日（神奈川）
Presentation conference
第62回日本ウイルス学会学術集会
Research subject
Euglena gtacilis Z 及びその糖貯蔵物質のインフルエンザ症状の緩和効果に関する検証
発表者
中島 綾香、滝本 博明、朝山 雄太、鈴木 健吾
Joint research destination
Kitasato University
2014年11月08日（奈良）
Presentation conference
第30回ユーグレナ研究会
Research subject
ユーグレナおよびパラミロンのインフルエンザ緩和効果
発表者
中島 綾香、滝本 博明、朝山 雄太、鈴木 健吾
Joint research destination
Kitasato University
ジャーナル
Cells. 2024 Jan 25;13(3):230. doi: 10.3390/cells13030230.
タイトル
Ergothioneine Prevents Neuronal Cell Death Caused by the Neurotoxin 6-Hydroxydopamine
Nutrients. 2022 Dec 7;14(24):5199. doi: 10.3390/nu14245199.
タイトル
Wild Watermelon-Extracted Juice Ingestion Reduces Peripheral Arterial Stiffness with an Increase in Nitric Oxide Production: A Randomized Crossover Pilot Study
Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum Adjuvants
著者
Masuda A, Lee JM, Miyata T, Mon H, Sato K, Oyama K, Sakurai Y, Yasuda J, Takahashi D, Ueda T, Kato Y, Nishida M, Karasaki N, Kakino K, Ebihara T, Nagasato T, Hino M, Nakashima A, Suzuki K, Tonooka Y, Tanaka M, Moriyama T, Nakatake H, Fujita R, Kusakabe T
Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum Adjuvants.
著者
Masuda, A., Lee, J. M., Miyata, T., Mon, H., Sato, K., Oyama, K., Sakurai, Y., Yasuda, J., Takahashi, D., Ueda, T., Kato, Y., Nishida, M., Karasaki, N., Kakino, K., Ebihara, T., Nagasato, T., Hino, M., Nakashima, A., Suzuki, K., Tonooka Y, Tanaka M, Moriyama T, Nakatake H, Fujita R, Kusakabe, T
Characterization of Chaetoceros lorenzianus-infecting DNA virus-derived promoters of genes from open reading frames of unknown function in Phaeodactylum tricornutum.
著者
Kadono, T., Tomaru, Y., Sato, N., Watanabe, Y., Suzuki, K., Yamada, K., & Adachi, M
Bioscience, Biotechnology, and Biochemistry, 85(9), 1932–1936.
タイトル
Development of quantitative analytical method for volatile thiol compound with LC-ESI-MS as nonvolatile derivative by integrating a thiol-specific derivatization.
International Journal of Molecular Sciences 2021, 22(6), 3124
タイトル
Beta-1,3 Oligoglucans Specifically Bind to Immune Receptor CD28 and May Enhance T Cell Activation.
著者
Comer, J., Bassette, M., Burghart, R., Loyd, M., Ishiguro, S., Azhagiya Singam, E. R., Vergara-Jaque, A., Nakashima, A., Suzuki, K., Geisbrecht, B. v, & Tamura, M
Abstract 2588: Oral administration of water extract from Euglena gracilis prevents lung carcinoma growth in mice by alteration of intestinal microbiota.
著者
Upreti, D., Ishiguro, S., Loyd, M., Robben, N., Cote, P., Phillips, M., Nakashima, A., Suzuki, K., Comer, J., & Tamura, M
Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice.
著者
Iida, M., Desamero, M. J., Yasuda, K., Nakashima, A., Suzuki, K., Chambers, J. K., Uchida, K., Ogawa, R., Hachimura, S., Nakayama, J., Kyuwa, S., Miura, K., Kakuta, S., & Hirayama, K
Effects of crystalline and amorphous forms of paramylon from Euglena gracilis on the development of water-immersion restraint stress-induced gastric ulcer.
著者
Ogushi, M., Imai, M., Yoshizawa, M., Suzuki, K., & Harada, N
Effects of euglena gracilis intake on mood and autonomic activity under mental workload, and subjective sleep quality: A randomized, double-blind, placebo-controlled trial.
著者
Nakashima, A., Yasuda, K., Murata, A., Suzuki, K., & Miura, N
Abstract 3459: Water extract from Euglena gracilis prevents lung carcinoma growth in mice via attenuation of myeloid-derived suppressor cells and granulocytes.
著者
Ishiguro, S., Upreti, D., Robben, N., Cote, P., Burghart, R., Ogun, D., Le, T., Delzeit, J., Carswell, J., Nakashima, A., Nakashima, A., Suzuki, K., Comer, J., & Tamura, M
Water extract from Euglena gracilis prevents lung carcinoma growth in mice by attenuation of the myeloid-derived cell population.
著者
Ishiguro, S., Upreti, D., Robben, N., Burghart, R., Loyd, M., Ogun, D., Le, T., Delzeit, J., Nakashima, A., Thakkar, R., Nakashima, A., Suzuki, K., Comer, J., & Tamura, M
Absorbance spectra of the hematochrome-like granules and eyespot of Euglena gracilis by scan-free absorbance spectral imaging A(x, y, λ) within the live cells
著者
Yamashita, K., Yagi, T., Isono, T., Nishiyama, Y., Hashimoto, M., Yamada, K., Suzuki, K., & Tokunaga, E
Simultaneous intake of Euglena gracilis and vegetables exerts synergistic anti-obesity and anti-inflammatory effects by modulating the gut microbiota in diet-induced obese mice.
著者
Okouchi, R., Shuang, E., Yamamoto, K., Ota, T., Seki, K., Imai, M., Ota, R., Asayama, Y., Nakashima, A., Suzuki, K., & Tsuduki, T
In Plant Biotechnology Journal (Vol. 17, Issue 11).
タイトル
Highly efficient transgene-free targeted mutagenesis and single-stranded oligodeoxynucleotide-mediated precise knock-in in the industrial microalga Euglena gracilis using Cas9 ribonucleoproteins.
著者
Nomura, T., Inoue, K., Uehara-Yamaguchi, Y., Yamada, K., Iwata, O., Suzuki, K., & Mochida, K
Current understanding of sulfur assimilation metabolism to biosynthesize L-cysteine and recent progress of its fermentative overproduction in microorganisms
Simultaneous Intake of Euglena Gracilis and Vegetables Synergistically Exerts an Anti-Inflammatory Effect and Attenuates Visceral Fat Accumulation by Affecting Gut Microbiota in Mice
Characterization of the eyespot and hematochrome-like granules of Euglena gracilis by scan-free absorbance spectral imaging A ( x , y , λ ) for quantification of carotenoids within the live cells.
著者
Yamashita, K., Yagi, T., Isono, T., Nishiyama, Y., Hashimoto, M., Yamada, K., Suzuki, K., & Tokunaga, E
Biochemical and Biophysical Research Communications, 494(1–2)
タイトル
Oral administration of Euglena gracilis Z and its carbohydrate storage substance provides survival protection against influenza virus infection in mice.
著者
Nakashima, A., Suzuki, K., Asayama, Y., Konno, M., Saito, K., Yamazaki, N., & Takimoto, H
Label-free chemical imaging of live Euglena gracilis by high-speed SRS spectral microscopy.
著者
Wakisaka, Y., Suzuki, Y., Tokunaga, K., Hirose, M., Domon, R., Akaho, R., Kuroshima, M., Tsumura, N., Shimobaba, T., Iwata, O., Suzuki, K., Nakashima, A., Goda, K., & Ozeki, Y
Animal Feed Science and Technology, Volume 212, February 2016, Pages 129-135
タイトル
Effects of Euglena (Euglena gracilis) supplemented to diet (forage: concentrate ratios of 60:40) on the basic ruminal fermentation and methane emissions in in vitro condition
Enhancement of photosynthetic capacity in Euglena gracilis by expression of cyanobacterial fructose-1,6- / sedoheptulose-1,7-bisphosphatase leads to increases in biomass and wax ester production
Journal of environmental biotechnology = 環境バイオテクノロジー学会誌 Vol. 14, No.1, 43-56
タイトル
Spirulina subsalsa var. salina var. nov. : Thermo-Halotolerant Cyanobacteria Accumulating Two Kinds of Compatible Solute, Originated from the Sultanate of Oman
著者
Kuroiwa Y, Rashid S. Tasaki M, Okamura K, Sueyoshi M, Nakashima A, Yoshida E, Suzuki K
Oral administration of paramylon, a beta-1,3-D-glucan isolated from Euglena gracilis Z inhibits development of atopic dermatitis-like skin lesions in NC / Nga mice.
著者
Sugiyama A, Hata S, Suzuki K, Yoshida E, Nakano R, Mitra S, Arashida R, Asayama Y, Yabuta Y, Takeuchi T.
Hepatoprotective effects of paramylon, a β-1, 3-D-Glucan isolated from Euglena gracilis Z, on acute liver injury induced by carbon tetrachloride in rats.
著者
Sugiyama, A., Suzuki, K., Mitra, S., Arashida, R., Yoshida, E., Nakano, R., Yabuta, Y., & Takeuchi, T
Hepatoprotective effects of paramylon, a beta-1, 3-D-glucan isolated from Euglena gracilis Z, on acute liver injury induced by carbon tetrachloride in rats.
著者
Sugiyama A, Suzuki K, Mitra S, Arashida R, Yoshida E, Nakano R, Yabuta Y, Takeuchi T.
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