{"id":38004,"date":"2025-09-24T15:30:00","date_gmt":"2025-09-24T06:30:00","guid":{"rendered":"https:\/\/www.euglena.jp\/news\/?p=38004"},"modified":"2025-11-21T09:11:17","modified_gmt":"2025-11-21T00:11:17","slug":"20250924-1","status":"publish","type":"post","link":"https:\/\/www.euglena.jp\/news\/20250924-1\/","title":{"rendered":"\u30e6\u30fc\u30b0\u30ec\u30ca\u306b\u304a\u3051\u308b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u975e\u5f93\u6765\u578b\u914d\u5217\u898f\u5247\u3092\u89e3\u660e"},"content":{"rendered":"\n<p><strong>\u30e6\u30fc\u30b0\u30ec\u30ca\u306b\u304a\u3051\u308b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u975e\u5f93\u6765\u578b\u914d\u5217\u898f\u5247\u3092\u89e3\u660e<br>\uff0d\u771f\u6838\u751f\u7269\u306e\u65b0\u305f\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5869\u57fa\u914d\u5217\u30eb\u30fc\u30eb\uff0d<\/strong><\/p>\n\n\n\n<p>\u3010\u6982\u8981\u3011<\/p>\n\n\n\n<p>\u3000\u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u7406\u7814\uff09\u74b0\u5883\u8cc7\u6e90\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30d0\u30a4\u30aa\u751f\u7523\u60c5\u5831\u7814\u7a76\u30c1\u30fc\u30e0\u306e\u91ce\u6751\u4fca\u5c1a\u5ba2\u54e1\u4e3b\u7ba1\u7814\u7a76\u54e1\uff08\u5c71\u5f62\u5927\u5b66\u8fb2\u5b66\u90e8\u51c6\u6559\u6388\uff09\u3001\u30ad\u30e0\u30fb\u30b8\u30e5\u30f3\u30b7\u30af\u7814\u7a76\u54e1\u3001\u6301\u7530\u6075\u4e00\u30c1\u30fc\u30e0\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\uff08\u6700\u5148\u7aef\u7814\u7a76\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u9023\u643a\uff08TRIP\uff09\u4e8b\u696d\u672c\u90e8\u85fb\u985e\u8cc7\u6e90\u30a2\u30c3\u30d7\u30b5\u30a4\u30af\u30eb\u7814\u7a76\u30c1\u30fc\u30e0\u526f\u30c1\u30fc\u30e0\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\u3001\u9577\u5d0e\u5927\u5b66\u60c5\u5831\u30c7\u30fc\u30bf\u79d1\u5b66\u90e8\u6559\u6388\u3001\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u6728\u539f\u751f\u7269\u5b66\u7814\u7a76\u6240\u5ba2\u54e1\u6559\u6388\uff09\u3001\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7cfb\u7814\u7a76\u79d1\u5316\u5b66\u5c02\u653b\u306e\u5408\u7530\u572d\u4ecb\u6559\u6388\u3001\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\u306e\u9234\u6728\u5065\u543e\u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30d5\u30a7\u30ed\u30fc\uff08\u7406\u7814TRIP\u4e8b\u696d\u672c\u90e8\u85fb\u985e\u8cc7\u6e90\u30a2\u30c3\u30d7\u30b5\u30a4\u30af\u30eb\u7814\u7a76\u30c1\u30fc\u30e0\u30c1\u30fc\u30e0\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\uff09\u3001\u9db4\u5ca1\u5de5\u696d\u9ad8\u7b49\u5c02\u9580\u5b66\u6821\u5275\u9020\u5de5\u5b66\u79d1\u57fa\u76e4\u6559\u80b2\u30b0\u30eb\u30fc\u30d7\u306e\u4f0a\u85e4\u5353\u6717\u51c6\u6559\u6388\u3001\u9ad8\u77e5\u5927\u5b66\u8fb2\u6797\u6d77\u6d0b\u79d1\u5b66\u90e8\u306e\u6afb\u4e95\u54f2\u4e5f\u6559\u6388\u3089\u306e\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u771f\u6838\u751f\u7269\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u904e\u7a0b\u3067\u3042\u308bmRNA\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0<sup>[1]<\/sup>\u306b\u304a\u3044\u3066\u3001\u30e6\u30fc\u30b0\u30ec\u30ca<sup>[2]<\/sup>\uff08\u548c\u540d\uff1a\u30df\u30c9\u30ea\u30e0\u30b7\uff09\u3067\u306f\u3001\u5f93\u6765\u306e\u771f\u6838\u751f\u7269\u3067\u5e83\u304f\u898b\u3089\u308c\u308b\u914d\u5217\u30eb\u30fc\u30eb\u306b\u52a0\u3048\u3066\u3001\u5168\u304f\u7570\u306a\u308b\u30eb\u30fc\u30eb\u306b\u5f93\u3046\u30a4\u30f3\u30c8\u30ed\u30f3<sup>[3]<\/sup>\u3092\u591a\u6570\u4f75\u7528\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br>\u3000\u672c\u7814\u7a76\u306f\u3001\u5f93\u6765\u578b\u3068\u975e\u5f93\u6765\u578b\u306e\u4e8c\u3064\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u304c\u5171\u5b58\u3059\u308b\u751f\u7269\u7a2e\u306e\u5b9f\u4f8b\u3092\u5206\u5b50\u907a\u4f1d\u5b66\u7684\u306b\u793a\u3057\u305f\u521d\u3081\u3066\u306e\u6210\u679c\u3067\u3042\u308a\u3001\u30b2\u30ce\u30e0\u7de8\u96c6<sup>[4]<\/sup>\u306b\u3088\u308b\u5408\u6210\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u5c0e\u5165\u3068\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u6a5f\u80fd\u306e\u767a\u73fe\u5236\u5fa1\u306a\u3069\u3078\u306e\u5fdc\u7528\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br>\u3000\u672c\u7814\u7a76\u306f\u3001\u79d1\u5b66\u96d1\u8a8c\u300e<a rel=\"noreferrer noopener\" href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2509937122\" data-type=\"URL\" data-id=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2509937122\" target=\"_blank\">Proceedings of the National Academy of Sciences<\/a><em>(<\/em><em>PNAS<\/em>\uff09\u300f\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u306b9\u670822\u65e5\u306e\u9031\u306b\u63b2\u8f09\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"521\" data-id=\"38005\"  src=\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/6f9722f6d8a6c937f399d0f622d92a61-1024x521.png\" alt=\"\" class=\"wp-image-38005\" srcset=\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/6f9722f6d8a6c937f399d0f622d92a61-1024x521.png 1024w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/6f9722f6d8a6c937f399d0f622d92a61-640x325.png 640w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/6f9722f6d8a6c937f399d0f622d92a61-300x153.png 300w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/6f9722f6d8a6c937f399d0f622d92a61-768x391.png 768w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/6f9722f6d8a6c937f399d0f622d92a61.png 1292w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div><\/figure>\n\n\n\n<p class=\"has-text-align-center has-small-font-size\">\u771f\u6838\u751f\u7269\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3068\u30e6\u30fc\u30b0\u30ec\u30ca\u30b2\u30ce\u30e0\u306e\u975e\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3<br>\uff08Created in BioRender. Mochida, K. (2025) 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class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"651\" src=\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/795316b92fc766b0181f6fef074f03fa-1024x651.png\" alt=\"\" class=\"wp-image-38006\" srcset=\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/795316b92fc766b0181f6fef074f03fa-1024x651.png 1024w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/795316b92fc766b0181f6fef074f03fa-640x407.png 640w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/795316b92fc766b0181f6fef074f03fa-300x191.png 300w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/795316b92fc766b0181f6fef074f03fa-768x488.png 768w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/795316b92fc766b0181f6fef074f03fa.png 1168w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center\">\u56f31 \u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30a2\u30b8\u30ea\u30b9\u306e\u30b2\u30ce\u30e0\u4e2d\u306e\u30a4\u30f3\u30c8\u30ed\u30f3<\/p>\n\n\n\n<p class=\"has-text-align-center has-small-font-size\">\uff08A\uff09\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30a2\u30b8\u30ea\u30b9\u306e\u30b2\u30ce\u30e0\u4e2d\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u304a\u3051\u308b\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\uff08CV\uff09\u3068\u975e\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\uff08NC\uff09\u306e\u5206\u5e03\u3002\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306f\u672b\u7aef\u914d\u5217\u304cGT-AG\u307e\u305f\u306fGC-AG\u30eb\u30fc\u30eb\u306b\u306e\u3063\u3068\u3063\u3066\u3044\u308b\u3082\u306e\u3001\u975e\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306f\u3001\u305d\u308c\u3089\u4ee5\u5916\u3092\u96c6\u8a08\u3057\u305f\u3002\uff08B\uff09\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\uff08CV\uff09\u3068\u975e\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\uff08NC\uff09\u306e\u30a8\u30af\u30bd\u30f3-\u30a4\u30f3\u30c8\u30ed\u30f3\u5883\u754c\u306e\u5869\u57fa\u914d\u5217\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3002\uff08C\uff09\u30a8\u30af\u30bd\u30f3-\u30a4\u30f3\u30c8\u30ed\u30f3\u5883\u754c\u304b\u3089\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u5185\u90e8\u306b\u5411\u304b\u3063\u3066\u306e\u5869\u57fa\u5bfe\u3092\u5f62\u6210\u3059\u308b\u5869\u57fa\u306e\u5206\u5e03\u306e\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\uff08CV\uff09\u3068\u975e\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\uff08NC\uff09\u306e\u6bd4\u8f03\u3002<\/p>\n\n\n\n<p>\u3000\u6b21\u306b\u3001\u3053\u308c\u3089\u306e\u914d\u5217\u306e\u7279\u5fb4\u304c\u30e6\u30fc\u30b0\u30ec\u30ca\u306e\u975e\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u6210\u5426\u306b\u95a2\u308f\u308b\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u307e\u305a\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30a2\u30b8\u30ea\u30b9\u306e\u30b2\u30ce\u30e0\u4e0a\u304b\u3089\u300150\u5869\u57fa\u7a0b\u5ea6\u306e\u77ed\u3044\u30a4\u30f3\u30c8\u30ed\u30f3\u914d\u5217\u3092\u898b\u3064\u3051\u3001\u305d\u308c\u3089\u3092\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308a\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30b0\u30e9\u30b7\u30ea\u30b9\uff08<em>Euglena gracilis<\/em>\uff09\u306e\u30d1\u30e9\u30df\u30ed\u30f3\uff08\u8caf\u8535\u591a\u7cd6\uff09\u5408\u6210\u306b\u95a2\u308f\u308b<em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u306e\u7b2c2\u30a8\u30af\u30bd\u30f3\u306b\u5c0e\u5165\u3057\u3001\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\uff08\u304b\u308a\u3085\u3046\uff09\u306e\u84c4\u7a4d\u3068<em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u304b\u3089\u8ee2\u5199\u3055\u308c\u305fmRNA\u306e\u914d\u5217\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u3053\u306e\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30a2\u30b8\u30ea\u30b9\u7531\u6765\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u3092\u5c0e\u5165\u3057\u305f\u30b0\u30e9\u30b7\u30ea\u30b9\u7cfb\u7d71\u306e\u7d30\u80de\u3067\u306f\u3001\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u306e\u84c4\u7a4d\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u308c\u3089\u306e\u7cfb\u7d71\u306b\u304a\u3044\u3066\u306f\u3001<em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u304b\u3089\u8ee2\u5199\u3055\u308c\u305fmRNA\u306e\u914d\u5217\u3067\u306f\u3001\u5c0e\u5165\u3057\u305f\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30a2\u30b8\u30ea\u30b9\u30a4\u30f3\u30c8\u30ed\u30f3\u304c\u6b63\u3057\u304f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3092\u53d7\u3051\u3066\u9664\u53bb\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u5f93\u3063\u3066\u3001\u540c\u69d8\u306e\u73fe\u8c61\u306f\u3001\u30b0\u30e9\u30b7\u30ea\u30b9\u306b\u7531\u6765\u3059\u308b49\u5869\u57fa\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u3067\u3082\u518d\u73fe\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u300150\u5869\u57fa\u7a0b\u5ea6\u306eDNA\u914d\u5217\u5185\u306b\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u306e\u975e\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u5fc5\u8981\u306a\u914d\u5217\u8981\u7d20\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u308c\u3089\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u5869\u57fa\u914d\u5217\u3092\u4eba\u70ba\u7684\u306b\u6539\u5909\u3057\u3066<em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u306b\u5c0e\u5165\u3057\u3001\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u306e\u84c4\u7a4d\u3068\u95a2\u9023\u6027\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u3069\u306e\u5869\u57fa\u914d\u5217\u306e\u7279\u5fb4\u304c\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u5fc5\u8981\u304b\u8abf\u3079\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f32\uff09\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"619\" height=\"1024\" src=\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/66caf9ce37399f5f2a455838389a18f4-619x1024.png\" alt=\"\" class=\"wp-image-38007\" srcset=\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/66caf9ce37399f5f2a455838389a18f4-619x1024.png 619w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/66caf9ce37399f5f2a455838389a18f4-387x640.png 387w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/66caf9ce37399f5f2a455838389a18f4-181x300.png 181w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/66caf9ce37399f5f2a455838389a18f4-768x1270.png 768w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/66caf9ce37399f5f2a455838389a18f4-929x1536.png 929w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/66caf9ce37399f5f2a455838389a18f4.png 1120w\" sizes=\"(max-width: 619px) 100vw, 619px\" \/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center\">\u56f32 <em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u7b2c2\u30a8\u30af\u30bd\u30f3\u5185\u90e8\u3078\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u5c0e\u5165\u3068\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u306e\u84c4\u7a4d<\/p>\n\n\n\n<p class=\"has-text-align-center has-small-font-size\">\uff08A\uff09\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30b0\u30e9\u30b7\u30ea\u30b9\u306e<em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u306e\u69cb\u9020\u3068\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308b\u7b2c2\u30a8\u30af\u30bd\u30f3\uff08E2\uff09\u5185\u90e8\u3078\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u5c0e\u5165\u3001\u304a\u3088\u3073\u5c0e\u5165\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u8a55\u4fa1\u306e\u6a21\u5f0f\u56f3\u3002\u5b9f\u9a13\u3067\u306f\u300150\u5869\u57fa\u7a0b\u5ea6\u306e\u975e\u5f93\u6765\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u914d\u5217\u3092\u5c0e\u5165\u3067\u304d\u308b1\u672c\u9396\u30aa\u30ea\u30b4\u30c7\u30aa\u30ad\u30b7\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08ssODN\uff09\u3092\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308a<em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u306e\u7b2c2\u30a8\u30af\u30bd\u30f3\u5185\u90e8\u3078\u5c0e\u5165\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a<em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u306e\u7b2c2\u30a8\u30af\u30bd\u30f3E2\u306fE2a\u3068E2b\u306b\u5206\u65ad\u3055\u308c\u308b\u3002E2a\u3068E2b\u306e\u9593\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u304c\u6b63\u3057\u304f\u30b9\u30d7\u30e9\u30b7\u30f3\u30b0\u3092\u53d7\u3051\u3066\u9664\u53bb\u3055\u308c\u308b\u3068\u3001\u30aa\u30ea\u30b8\u30ca\u30eb\u3068\u540c\u3058\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u30b3\u30fc\u30c9\u3059\u308bmRNA\u304c\u3064\u304f\u3089\u308c\u308b\u305f\u3081\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u306e\u7d30\u80de\u5185\u3067\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u304c\u3064\u304f\u3089\u308c\u308b\u3002\u4e00\u65b9\u3001\u6b63\u3057\u304f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u306a\u3044\u5834\u5408\u306f\u3001\u6b63\u3057\u3044mRNA\u304c\u3064\u304f\u3089\u308c\u306a\u3044\u305f\u3081\u3001\u7d30\u80de\u5185\u3067\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u306f\u307b\u3068\u3093\u3069\u89b3\u5bdf\u3055\u308c\u306a\u3044\u3002\uff08B\uff09\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30a2\u30b8\u30ea\u30b9\u7531\u6765\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\uff08EaNC-INT1\u304a\u3088\u3073EaNC-INT3\uff09\u3068\u30b0\u30e9\u30b7\u30ea\u30b9\u7531\u6765\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\uff08EgNC-INT1\uff09\u3092\u5c0e\u5165\u3057\u305f\u30b0\u30e9\u30b7\u30ea\u30b9\u7d30\u80de\u306e\u89b3\u5bdf\u7d50\u679c\u3002\uff08C\uff09\u30a4\u30f3\u30c8\u30ed\u30f3\u3092\u5c0e\u5165\u3057\u305f\u7d30\u80de\u96c6\u56e3\u306b\u304a\u3051\u308b\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u84c4\u7a4d\u7d30\u80de\u306e\u5272\u5408\u3002<\/p>\n\n\n\n<p>\u3000\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u306e\u84c4\u7a4d\u3092\u6307\u6a19\u3068\u3057\u305f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u8a55\u4fa1\u65b9\u6cd5\u3092\u7528\u3044\u3066\u3001\u307e\u305a\u3001\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u7aef\u90e8\u306b\u7279\u5fb4\u7684\u306aCAG\u3068CTG\u306e\u30e2\u30c1\u30fc\u30d5\u914d\u5217\u304c\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u5fc5\u8981\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u3001\u5929\u7136\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u3053\u306e\u90e8\u5206\u306e\u914d\u5217\u30921\u5869\u57fa\u3054\u3068\u306b\u7f6e\u63db\u3057\u305f\u5408\u6210\u30a4\u30f3\u30c8\u30ed\u30f3\u914d\u5217\u3092<em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u306b\u5c0e\u5165\u3057\u3066\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u6210\u5426\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u7d50\u679c\u3068\u3057\u3066\u3001\u3053\u306e3\u5869\u57fa\u306e\u30e2\u30c1\u30fc\u30d5\u306e\u5869\u57fa\u914d\u5217\u3092\u5909\u66f4\u3059\u308b\u3068\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u306a\u304f\u306a\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u3053\u306e\u5869\u57fa\u914d\u5217\u304c\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br>\u3000\u6b21\u306b\u3001\u524d\u306e\u30a8\u30af\u30bd\u30f3\u306e\u7d42\u7aef\u304b\u3089CAG\u307e\u3067\u306e\u5869\u57fa\u6570\u3068CTG\u304b\u3089\u6b21\u306e\u30a8\u30af\u30bd\u30f3\u307e\u3067\u306e\u5869\u57fa\u6570\u306b\u30eb\u30fc\u30eb\u6027\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u3001\u305d\u308c\u305e\u308c\u306e\u9818\u57df\u306e\u5869\u57fa\u6570\u3092\u5909\u3048\u305f\u5408\u6210\u30a4\u30f3\u30c8\u30ed\u30f3\u914d\u5217\u3092<em>EgGSL2<\/em>\u907a\u4f1d\u5b50\u306b\u5c0e\u5165\u3057\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u6210\u5426\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u3059\u308b\u3068\u3001\u524d\u306e\u30a8\u30af\u30bd\u30f3\u306e\u7d42\u7aef\u304b\u3089CAG\u307e\u3067\u306f3\u5869\u57fa\u3067\u3042\u308b\u5fc5\u8981\u304c\u3042\u308a\u3001CTG\u304b\u3089\u6b21\u306e\u30a8\u30af\u30bd\u30f3\u307e\u3067\u306e\u5869\u57fa\u6570\u306f5\u5869\u57fa\u304c\u6700\u3082\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u52b9\u7387\u304c\u9ad8\u304f\u3001\u3053\u306e\u5869\u57fa\u30921\u5869\u57fa\u305a\u3064\u6e1b\u3089\u3059\u3068mRNA\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u304c\u5f90\u3005\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08\u56f33\uff09\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001\u30a4\u30f3\u30c8\u30ed\u30f3\u4e0a\u306eCAG\u3068CTG\u306e\u30e2\u30c1\u30fc\u30d5\u914d\u5217\u3068\u30a8\u30af\u30bd\u30f3\u9593\u306e\u5869\u57fa\u6570\u3082\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br>\u3000\u3055\u3089\u306b\u3001\u30a4\u30f3\u30c8\u30ed\u30f3\u5f8c\u306e\u30a8\u30af\u30bd\u30f3\u306e\u6700\u521d\u306e\u5869\u57fa\u306fA\u304bG\uff08\u30d7\u30ea\u30f3\u5869\u57fa\uff09\u306b\u504f\u3063\u3066\u3044\u308b\u70b9\u306b\u3064\u3044\u3066\u3082\u3001\u4ed6\u306e\u5869\u57fa\u3067\u3042\u308bT\u3084C\u306b\u7de8\u96c6\u3057\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3068\u306e\u95a2\u9023\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u7d50\u679c\u3068\u3057\u3066\u3001\u3053\u306e\u30a8\u30af\u30bd\u30f3\u306e\u958b\u59cb\u5869\u57fa\u3082\u30d7\u30ea\u30f3\u5869\u57fa\u3067\u3042\u308b\u3053\u3068\u304c\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/fc73d1948c993f0e72455369b56b010d-466x1024.png\" alt=\"\" class=\"wp-image-38008\" width=\"560\" height=\"1231\" srcset=\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/fc73d1948c993f0e72455369b56b010d-466x1024.png 466w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/fc73d1948c993f0e72455369b56b010d-137x300.png 137w, https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2025\/09\/fc73d1948c993f0e72455369b56b010d.png 583w\" sizes=\"(max-width: 560px) 100vw, 560px\" \/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center\">\u56f33 \u5909\u7570\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u5c0e\u5165\u3068\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u306e\u84c4\u7a4d\u306b\u3088\u308b\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u8a55\u4fa1<\/p>\n\n\n\n<p class=\"has-text-align-center has-small-font-size\">\uff08A\uff09CAG\u30e2\u30c1\u30fc\u30d5\u3068CTG\u30e2\u30c1\u30fc\u30d5\u30921\u5869\u57fa\u305a\u3064\u7de8\u96c6\u3059\u308b\u305f\u3081\u306e\u6539\u5909\u30a4\u30f3\u30c8\u30ed\u30f3\u914d\u5217\u3002\uff08B\uff09\uff08A\uff09\u306e\u6539\u5909\u30a4\u30f3\u30c8\u30ed\u30f3\u914d\u5217\u3092\u5c0e\u5165\u3057\u305f\u7d30\u80de\u96c6\u56e3\u306b\u304a\u3051\u308b\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u84c4\u7a4d\u7d30\u80de\u306e\u5272\u5408\u3002\uff08C\uff09\u30a4\u30f3\u30c8\u30ed\u30f3\u958b\u59cb\u70b9\u3068CAG\u30e2\u30c1\u30fc\u30d5\u306e\u9593\u3001\u304a\u3088\u3073CTG\u30e2\u30c1\u30fc\u30d5\u304b\u3089\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u7d42\u7aef\u307e\u3067\u306e\u9593\u306e\u5869\u57fa\u6570\u3068\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u95a2\u9023\u6027\u3092\u8abf\u3079\u308b\u305f\u3081\u306e\u6539\u5909\u30a4\u30f3\u30c8\u30ed\u30f3\u914d\u5217\u3002\uff08D\uff09\uff08C\uff09\u306e\u6539\u5909\u30a4\u30f3\u30c8\u30ed\u30f3\u914d\u5217\u3092\u5c0e\u5165\u3057\u305f\u7d30\u80de\u96c6\u56e3\u306b\u304a\u3051\u308b\u30d1\u30e9\u30df\u30ed\u30f3\u9846\u7c92\u84c4\u7a4d\u7d30\u80de\u306e\u5272\u5408\u3002Cent. -5bp\u3068Cent. 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class=\"has-small-font-size\">\u6ce8\uff092019\u5e746\u670817\u65e5\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u300c\u30df\u30c9\u30ea\u30e0\u30b7\u3067\u306e\u9ad8\u52b9\u7387\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u6210\u529f\u300d<br><a href=\"https:\/\/www.riken.jp\/press\/2019\/20190617_1\/\">https:\/\/www.riken.jp\/press\/2019\/20190617_1\/<\/a><\/p>\n\n\n\n<p>\u3010\u4eca\u5f8c\u306e\u671f\u5f85\u3011<br>\u3000\u672c\u7814\u7a76\u306b\u3088\u308a\u3001\u771f\u6838\u751f\u7269\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u6a5f\u69cb\u306b\u304a\u3044\u3066\u3001\u5e38\u8b58\u7684\u306aGT-AG\u30eb\u30fc\u30eb\u3068\u306f\u5168\u304f\u7570\u306a\u308b\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u305f\u3081\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u914d\u5217\u30eb\u30fc\u30eb\u304c\u30e6\u30fc\u30b0\u30ec\u30ca\u306e\u591a\u304f\u306e\u907a\u4f1d\u5b50\u3067\u63a1\u7528\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<br>\u3000\u7814\u7a76\u306e\u51fa\u767a\u70b9\u306f\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u306e\u907a\u4f1d\u5b50\u69cb\u9020\u3092\u7db2\u7f85\u7684\u306b\u8abf\u3079\u305f\u969b\u306b\u3001GT-AG\u30eb\u30fc\u30eb\u306b\u57fa\u3065\u304f\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u7528\u3044\u308b\u30bd\u30d5\u30c8\u30a6\u30a8\u30a2\u3067\u306f\u3001\u907a\u4f1d\u5b50\u69cb\u9020\u3092\u307b\u3068\u3093\u3069\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u554f\u984c\u306b\u51fa\u5408\u3063\u305f\u3053\u3068\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308a\u5869\u57fa\u66f8\u304d\u63db\u3048\u3084\u6b63\u78ba\u306a\u914d\u5217\u5c0e\u5165\u304c\u53ef\u80fd\u306b\u306a\u3063\u305f\u3053\u3068\u3067\u3001\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u5869\u57fa\u306e\u91cd\u8981\u6027\u30921\u5869\u57fa\u5358\u4f4d\u3067\u691c\u8a3c\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002<br>\u3000\u672c\u7814\u7a76\u3067\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u53ef\u5426\u3092\u8abf\u3079\u305f\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30b0\u30e9\u30b7\u30ea\u30b9\u306f\u3001\u5065\u5eb7\u98df\u54c1\u3084\u30d0\u30a4\u30aa\u71c3\u6599\u306e\u539f\u6599\u3068\u3057\u3066\u5229\u7528\u304c\u9032\u3080\u5fae\u7d30\u85fb\u985e\u3067\u3042\u308a\u3001\u907a\u4f1d\u5b50\u69cb\u9020\u306e\u6b63\u78ba\u306a\u7406\u89e3\u306f\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308b\u6539\u826f\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u672c\u6210\u679c\u306f\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u306b\u304a\u3051\u308b\u6709\u7528\u7269\u8cea\u306e\u751f\u7523\u306b\u95a2\u308f\u308b\u4ee3\u8b1d\u7d4c\u8def\u306e\u540c\u5b9a\u3084\u6539\u5909\u3092\u53ef\u80fd\u306b\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u4e8c\u9178\u5316\u70ad\u7d20\u306e\u56fa\u5b9a\u3068\u8cc7\u6e90\u5316\u3092\u76ee\u7684\u3068\u3057\u3066\u30d0\u30a4\u30aa\u30de\u30b9\u306e\u751f\u7523\u6027\u3092\u5411\u4e0a\u3059\u308b\u305f\u3081\u306e\u5f62\u8cea\u306e\u6539\u826f\u306b\u3064\u306a\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br>\u3000\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u56fd\u969b\u9023\u5408\u304c\u5b9a\u3081\u305f17\u306e\u76ee\u6a19\u300c\u6301\u7d9a\u53ef\u80fd\u306a\u958b\u767a\u76ee\u6a19\uff08SDGs\uff09<sup>[7]<\/sup>\u300d\u306e\u3046\u3061\u3001\u300c13.\u6c17\u5019\u5909\u52d5\u306b\u5177\u4f53\u7684\u306a\u5bfe\u7b56\u3092\u300d\u300c2.\u98e2\u9913\u3092\u30bc\u30ed\u306b\u300d\u300c7.\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u307f\u3093\u306a\u306b\u305d\u3057\u3066\u30af\u30ea\u30fc\u30f3\u306b\u300d\u306b\u8ca2\u732e\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3010\u8ad6\u6587\u60c5\u5831\u3011<br>\uff1c\u30bf\u30a4\u30c8\u30eb\uff1e<br><a rel=\"noreferrer noopener\" href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2509937122\" data-type=\"URL\" data-id=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2509937122\" target=\"_blank\">Genetic dissection of nonconventional introns reveals co-dominant noncanonical splicing code in Euglena<\/a><br>\uff1c\u8457\u8005\u540d\uff1e<br>Toshihisa Nomura, June-Sik Kim, Osamu Iwata, Koji Yamada, Kohei Atsuji, Yukiko Uehara-Yamaguchi, Takuhiro Yoshida, Komaki Inoue, Kotaro Takahagi, Tetsuya Sakurai, Kazuo Shinozaki, Takuro Ito, Kengo Suzuki, Keisuke Goda, and Keiichi Mochida<br>\uff1c\u96d1\u8a8c\uff1e<br><em>Proceedings of the National Academy of Sciences<\/em>\uff08<em>PNAS<\/em>\uff09<br>\uff1cDOI\uff1e<br>10.1073\/pnas.2509937122<\/p>\n\n\n\n<p>\u3010\u88dc\u8db3\u8aac\u660e\u3011<br>[1] 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\u30a4\u30f3\u30c8\u30ed\u30f3\u3001\u30a8\u30af\u30bd\u30f3<br>\u907a\u4f1d\u5b50\u306f\u300c\u30a8\u30af\u30bd\u30f3\u300d\uff08\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8a2d\u8a08\u56f3\u3068\u3057\u3066\u4f7f\u308f\u308c\u308b\u90e8\u5206\uff09\u3068\u300c\u30a4\u30f3\u30c8\u30ed\u30f3\u300d\uff08\u6700\u7d42\u7684\u306b\u306f\u4f7f\u308f\u308c\u306a\u3044\u90e8\u5206\uff09\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u308b\u3002\u907a\u4f1d\u5b50\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3064\u304f\u3089\u308c\u308b\u969b\u3001\u307e\u305amRNA\u306bDNA\u306e\u5869\u57fa\u914d\u5217\u306e\u60c5\u5831\u304c\u8ee2\u5199\u3055\u308c\u3001\u305d\u306e\u5f8c\u30a4\u30f3\u30c8\u30ed\u30f3\u304c\u53d6\u308a\u9664\u304b\u308c\u3066\u30a8\u30af\u30bd\u30f3\u304c\u3064\u306a\u304e\u5408\u308f\u3055\u308c\u3001\u6210\u719f\u3057\u305fmRNA\u304c\u3067\u304d\u308b\u3002\u3053\u306e\u4ed5\u7d44\u307f\u306b\u3088\u308a\u3001\u30a8\u30af\u30bd\u30f3\u306e\u3064\u306a\u304e\u65b9\u3092\u5909\u3048\u308b\u9078\u629e\u7684\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u3088\u308a\u540c\u3058\u907a\u4f1d\u5b50\u304b\u3089\u7570\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3064\u304f\u308b\u3053\u3068\u3082\u53ef\u80fd\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<p>[4] 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