{"id":37796,"date":"2025-08-01T15:30:00","date_gmt":"2025-08-01T06:30:00","guid":{"rendered":"https:\/\/www.euglena.jp\/news\/?p=37796"},"modified":"2025-11-21T09:08:08","modified_gmt":"2025-11-21T00:08:08","slug":"20250801-1","status":"publish","type":"post","link":"https:\/\/www.euglena.jp\/news\/20250801-1\/","title":{"rendered":"\u7d76\u98df\u6642\u306e\u30e6\u30fc\u30b0\u30ec\u30ca\u7531\u6765\u30d1\u30e9\u30df\u30ed\u30f3\u306e\u6442\u53d6\u304c\u3001\u8178\u5185\u74b0\u5883\u304a\u3088\u3073\u514d\u75ab\u6a5f\u80fd\u3092\u77ed\u671f\u9593\u3067\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f"},"content":{"rendered":"\n

\u7d76\u98df\u6642\u306e\u30e6\u30fc\u30b0\u30ec\u30ca\u7531\u6765\u30d1\u30e9\u30df\u30ed\u30f3\u306e\u6442\u53d6\u304c\u3001
\u8178\u5185\u74b0\u5883\u304a\u3088\u3073\u514d\u75ab\u6a5f\u80fd\u3092\u77ed\u671f\u9593\u3067\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u3092\u78ba\u8a8d
\u7d76\u98df\u304c\u8178\u5185\u7d30\u83cc\u53e2\u306e\u518d\u69cb\u6210\u3092\u4fc3\u3057\u3001\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u793a\u5506<\/p>\n\n\n\n

\u3000\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u672c\u793e\uff1a\u6771\u4eac\u90fd\u6e2f\u533a\u3001\u4ee3\u8868\u53d6\u7de0\u5f79\u793e\u9577\uff1a\u51fa\u96f2\u5145\uff09\u3068\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u3068\u5317\u91cc\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u7d76\u98df\u6642\u306b\u5fae\u7d30\u85fb\u985e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u548c\u540d\uff1a\u30df\u30c9\u30ea\u30e0\u30b7\u3001\u4ee5\u4e0b\u300c\u30e6\u30fc\u30b0\u30ec\u30ca\u300d\uff09\u7531\u6765\u306e\u30d1\u30e9\u30df\u30ed\u30f3\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u8178\u5185\u306e\u6709\u7528\u83cc\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\u5c5e\u306e\u9078\u629e\u7684\u5897\u52a0\u304c\u307f\u3089\u308c\u3001\u307e\u305f\u3001\u7cde\u4fbf\u4e2d\u306e\u514d\u75ab\u306b\u95a2\u308f\u308b\u7269\u8ceaIgA\u306e\u7523\u751f\u304c\u9ad8\u307e\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u6210\u679c\u306f\u5b66\u8853\u96d1\u8a8cBMC Microbiology\u306b\u63b2\u8f09\u203b1<\/sup>\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n


<\/p>\n\n\n\n

\u25a0\u8178\u5185\u7d30\u83cc\u53e2\uff08\u8178\u5185\u30d5\u30ed\u30fc\u30e9\uff09\u3068\u7d76\u98df\u306e\u95a2\u4fc2<\/strong><\/strong><\/p>\n\n\n\n

\u3000\u8178\u5185\u7d30\u83cc\u53e2\u306f\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068\u3082\u547c\u3070\u308c\u3001\u4f55\u5146\u3082\u306e\u5fae\u751f\u7269\u304b\u3089\u306a\u308b\u8907\u96d1\u306a\u751f\u614b\u7cfb\u3067\u3001\u708e\u75c7\u30fb\u4ee3\u8b1d\u30fb\u8a8d\u77e5\u306a\u3069\u306e\u5065\u5eb7\u306b\u95a2\u4e0e\u3057\u3001\u98df\u4e8b\u5185\u5bb9\u306b\u3088\u3063\u3066\u305d\u306e\u69cb\u6210\u304c\u5909\u5316\u3059\u308b\u305f\u3081\u3001\u98df\u4e8b\u4ecb\u5165\u306b\u3088\u308b\u5065\u5eb7\u6539\u5584\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u98df\u7269\u7e4a\u7dad\u306a\u3069\u306eMAC\u203b2<\/sup>\u306f\u3001\u6442\u53d6\u3059\u308b\u3068\u8178\u5185\u7d30\u83cc\u306b\u3088\u3063\u3066\u767a\u9175\u3055\u308c\u3001\u77ed\u9396\u8102\u80aa\u9178\u306a\u3069\u306e\u6709\u76ca\u306a\u4ee3\u8b1d\u7523\u7269\u3092\u751f\u6210\u3057\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u69cb\u6210\u3092\u5909\u5316\u3055\u305b\u308b\u300c\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u300d\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u8178\u5185\u74b0\u5883\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u6052\u5e38\u6027\u306b\u3088\u308a\u3001MAC\u3092\u542b\u3080\u98df\u4e8b\u4ecb\u5165\u3060\u3051\u3067\u306f\u3001\u8178\u5185\u7d30\u83cc\u53e2\u3092\u77ed\u671f\u9593\u3067\u5927\u304d\u304f\u5909\u3048\u308b\u306e\u306f\u56f0\u96e3\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000\u7d76\u98df\u3068\u306f\u3001\u98df\u7269\u3092\u4e00\u5207\u6442\u53d6\u3057\u306a\u3044\u72b6\u614b\u3092\u6307\u3057\u3001\u533b\u7642\u73fe\u5834\u306b\u304a\u3044\u3066\u306f\u691c\u67fb\u3084\u624b\u8853\u306e\u524d\u5f8c\u306b\u3001\u307e\u305f\u300c\u65ad\u98df\u300d\u3068\u3057\u3066\u5065\u5eb7\u6cd5\u3001\u5b97\u6559\u7684\u306a\u5100\u5f0f\u306b\u304a\u3044\u3066\u884c\u308f\u308c\u307e\u3059\u3002\u7d76\u98df\u306b\u3088\u3063\u3066\u8178\u5185\u7d30\u83cc\u53e2\u306e\u69cb\u6210\u304c\u5909\u5316\u3057\u3001\u4e00\u6642\u7684\u306b\u305d\u306e\u6052\u5e38\u6027\u304c\u5d29\u308c\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u74b0\u5883\u304cMAC\u306b\u3088\u308b\u5909\u5316\u3092\u53d7\u3051\u5165\u308c\u3084\u3059\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u203b1 Sato K, Nakashima A, Fukuda S, Inoue J, Kim YG. Fasting builds a favorable environment for effective gut microbiota modulation by microbiota-accessible carbohydrates. BMC Microbiol. 2025 Jul 5;25(1):414. doi: 10.1186\/s12866-025-04140-y. PMID: 40618036; PMCID: PMC12228412 (https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-025-04140-y)
\u203b2 Microbiota-Accessible Carbohydrates\uff1b\u4eba\u9593\u306e\u6d88\u5316\u9175\u7d20\u3067\u306f\u5206\u89e3\u3055\u308c\u306b\u304f\u3044\u70ad\u6c34\u5316\u7269\u3067\u3042\u308a\u3001\u8178\u5185\u7d30\u83cc\u306b\u3088\u3063\u3066\u5206\u89e3\u30fb\u767a\u9175\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u74b0\u5883\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002\u4e3b\u306b\u98df\u7269\u7e4a\u7dad\u3084\u30aa\u30ea\u30b4\u7cd6\u306a\u3069\u3092\u6307\u3059<\/p>\n\n\n\n


<\/p>\n\n\n\n

\u25a0\u7814\u7a76\u306e\u5185\u5bb9\u3068\u7d50\u679c<\/strong>

\u3000\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u7d76\u98df\u304c\u8178\u5185\u7d30\u83cc\u53e2\u306e\u69cb\u6210\u3068MAC\u306b\u3088\u308b\u8abf\u7bc0\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3092\u3001\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u691c\u8a3c\u3057\u305f\u7d50\u679c\u300136\u6642\u9593\u306e\u7d76\u98df\u306b\u3088\u308a\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5927\u304d\u304f\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u307e\u305f\u3001\u7d76\u98df\u6642\u306bMAC\u3092\u6442\u53d6\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001MAC\u5358\u72ec\u6442\u53d6\u3088\u308a\u3082\u7279\u5b9a\u306e\u7d30\u83cc\u304c\u9855\u8457\u306b\u5897\u52a0\u3057\u3001\u3055\u3089\u306bMAC\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u5897\u52a0\u3059\u308b\u7d30\u83cc\u306e\u7a2e\u985e\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u3053\u3068\u304b\u3089\u3001\u7d76\u98df\u306b\u3088\u308a\u8178\u5185\u74b0\u5883\u304c\u5909\u5316\u3057\u3001MAC\u306b\u5bfe\u3059\u308b\u8178\u5185\u7d30\u83cc\u306e\u611f\u53d7\u6027\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u30d1\u30e9\u30df\u30ed\u30f3\u306f\u3001\u4eca\u56de\u306e\u5b9f\u9a13\u306b\u7528\u3044\u305fMAC\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u4ee5\u4e0b\u306e\u901a\u308a\u3001\u7d76\u98df\u6642\u306e\u30d1\u30e9\u30df\u30ed\u30f3\u6442\u53d6\u304c\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002
\u3000<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u56f31\uff1a\u7d76\u98df\u6642\u306e\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5909\u5316<\/p>\n\n\n\n

\u203b1\u3088\u308a\u3001\u56f31\uff08c\uff09\u3092\u5f15\u7528<\/p>\n\n\n\n


\u3000\u305d\u306e\u7d50\u679c\u3001\u7d76\u98df\uff0b\u30d1\u30e9\u30df\u30ed\u30f3\u6442\u53d6\u304c\u3001\u7279\u5b9a\u306e\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5360\u6709\u7387\u3092\u5897\u52a0\u3055\u305b\u3001\u7cde\u4fbf\u4e2dIgA\u7523\u751f\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002
\u3000\u30de\u30a6\u30b9\u30926\u7fa4\u306b\u5206\u3051\u3001\u901a\u5e38\u98fc\u6599\u6442\u53d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3001\u7d76\u98df\u306a\u3057\u30e6\u30fc\u30b0\u30ec\u30ca\u6442\u53d6\u7fa4\u3001\u7d76\u98df\u306a\u3057\u30d1\u30e9\u30df\u30ed\u30f3\u6442\u53d6\u7fa4\u3001\u7d76\u98df\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3001\u7d76\u98df\u3042\u308a\u30e6\u30fc\u30b0\u30ec\u30ca\u6442\u53d6\u7fa4\u3001\u7d76\u98df\u3042\u308a\u30d1\u30e9\u30df\u30ed\u30f3\u6442\u53d6\u7fa4\u3092\u8a2d\u7f6e\u3057\u3001\u7d76\u98df\u3042\u308a\u306e\u7fa4\u306b\u306f\u300136\u6642\u9593\u306e\u7d76\u98df\u4e2d\u306b\u30e6\u30fc\u30b0\u30ec\u30ca\u307e\u305f\u306f\u30d1\u30e9\u30df\u30ed\u30f3\u3092\u6442\u53d6\u3055\u305b\u3001\u8178\u5185\u7d30\u83cc\u53e2\u3078\u306e\u5f71\u97ff\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u7d76\u98df\u306b\u3088\u3063\u3066\u8178\u5185\u7d30\u83cc\u53e2\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5909\u5316\u3057\u3001\u3055\u3089\u306b\u7d76\u98df\u4e2d\u306e\u30d1\u30e9\u30df\u30ed\u30f3\u6442\u53d6\u3067\u3001Bacteroides \u3084[Eubacterium] coprostanoligenes \u306e\u76f8\u5bfe\u5360\u6709\u7387\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\uff08\u56f32\uff09\u3002  Bacteroides \u306f\u3001\u8178\u7ba1\u514d\u75ab\u306e\u6210\u719f\u3068\u5b89\u5b9a\u5316\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3001[Eubacterium] coprostanoligenes \u306f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n


<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u56f32\uff1a\u5404\u7fa4\u306e\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5909\u5316<\/p>\n\n\n\n

\u203b1\u3088\u308a\u3001\u56f35\uff08d\uff09\uff08e\uff09\u3092\u5f15\u7528
One-way ANOVA followed by Dunnett\u2019s test.,  ****p<0.0001, **p<0.01, *p<0.05<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3000
\u3000\u307e\u305f\u3001\u305d\u306e\u6642\u306e\u7cde\u4fbf\u4e2d\u306eIgA\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001\u7d76\u98df\uff0b\u30d1\u30e9\u30df\u30ed\u30f3\u6442\u53d6\u7fa4\u306b\u304a\u3044\u3066\u3001\u6709\u610f\u306b\u7523\u751f\u304c\u591a\u304f\u306a\u308a\u307e\u3057\u305f\uff08\u56f33\uff09\u3002IgA\u306f\u4f53\u5185\u3067\u7523\u751f\u3055\u308c\u308b\u6297\u4f53\uff08\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\uff09\u306e\u4e00\u7a2e\u3067\u3001\u7279\u306b\u7c98\u819c\u306e\u514d\u75ab\u9632\u5fa1\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002IgA\u306e\u8a98\u5c0e\u306b\u3082\u95a2\u308f\u308b\u3068\u3055\u308c\u3066\u3044\u308b\u3001Bacteroides\u306e\u76f8\u5bfe\u5360\u6709\u7387\u304c\u5897\u52a0\u3057\u305f\u3053\u3068\u304c\u95a2\u308f\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002
<\/p>\n\n\n\n

<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u56f33\uff1a\u5404\u7fa4\u306e\u7cde\u4fbf\u4e2dIgA\u306e\u7523\u751f\u91cf<\/p>\n\n\n\n

\u203b1\u3088\u308a\u3001\u56f35\uff08g\uff09\u3092\u5f15\u7528
One-way ANOVA followed by Dunnett\u2019s test.,  **p<0.01<\/p>\n\n\n\n


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\uff1c\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\u306b\u3064\u3044\u3066\uff1e
2005\u5e74\u306b\u4e16\u754c\u3067\u521d\u3081\u3066\u5fae\u7d30\u85fb\u985e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u548c\u540d\uff1a\u30df\u30c9\u30ea\u30e0\u30b7\uff09\u306e\u98df\u7528\u5c4b\u5916\u5927\u91cf\u57f9\u990a\u6280\u8853\u306e\u78ba\u7acb\u306b\u6210\u529f\u3002\u300cSustainability First\uff08\u30b5\u30b9\u30c6\u30ca\u30d3\u30ea\u30c6\u30a3\u30fb\u30d5\u30a1\u30fc\u30b9\u30c8\uff09\u300d\u3092\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30d5\u30a3\u30ed\u30bd\u30d5\u30a3\u30fc\u3068\u5b9a\u7fa9\u3057\u3001\u5fae\u7d30\u85fb\u985e\u30e6\u30fc\u30b0\u30ec\u30ca\u3001\u30af\u30ed\u30ec\u30e9\u306a\u3069\u3092\u6d3b\u7528\u3057\u305f\u98df\u54c1\u3001\u5316\u7ca7\u54c1\u7b49\u306e\u958b\u767a\u30fb\u8ca9\u58f2\u3001\u30d0\u30a4\u30aa\u71c3\u6599\u306e\u88fd\u9020\u958b\u767a\u3001\u672a\u5229\u7528\u8cc7\u6e90\u7b49\u3092\u6d3b\u7528\u3057\u305f\u30b5\u30b9\u30c6\u30ca\u30d6\u30eb\u30a2\u30b0\u30ea\u30c6\u30c3\u30af\u9818\u57df\u306a\u3069\u306e\u4e8b\u696d\u3092\u5c55\u958b\u30022014\u5e74\u3088\u308a\u3001\u30d0\u30f3\u30b0\u30e9\u30c7\u30b7\u30e5\u306e\u5b50\u3069\u3082\u305f\u3061\u306b\u8c4a\u5bcc\u306a\u6804\u990a\u7d20\u3092\u6301\u3064\u30e6\u30fc\u30b0\u30ec\u30ca\u30af\u30c3\u30ad\u30fc\u3092\u5c4a\u3051\u308b\u300c\u30e6\u30fc\u30b0\u30ec\u30caGENKI\u30d7\u30ed\u30b0\u30e9\u30e0\u300d\u3092\u3001\u7d99\u7d9a\u7684\u306b\u5b9f\u65bd\u3057\u3066\u3044\u308b\u3002https:\/\/euglena.jp<\/a>
<\/p>\n\n\n\n

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