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\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u672c\u7a2e\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b2\u30ce\u30e0\u6539\u5909\u6280\u8853\u3092\u62e1\u5f35\u3059\u308b\u305f\u3081\u3001Cas9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\uff08\u6838\u9178\u5206\u89e3\u9175\u7d20\uff09\u3068\u306f\u7570\u306a\u3063\u305f\u6027\u8cea\u3092\u6709\u3059\u308bCas12a\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u3092\u7528\u3044\u3001\u304b\u3064\u7dfb\u5bc6\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u30b2\u30ce\u30e0\u7de8\u96c6\u65b9\u6cd5\u306e\u78ba\u7acb\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000<\/p>\n\n\n\n

\u6ce81\uff092019\u5e746\u670817\u65e5\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u300c\u30df\u30c9\u30ea\u30e0\u30b7\u3067\u306e\u9ad8\u52b9\u7387\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u6210\u529f\u300d
https:\/\/www.riken.jp\/press\/2019\/20190617_1\/<\/a>
\u6ce82\uff092022\u5e749\u67089\u65e5\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u300c\u30b2\u30ce\u30e0\u7de8\u96c6\u3067\u904a\u6cf3\u4e0d\u5168\u30df\u30c9\u30ea\u30e0\u30b7\u306e\u4f5c\u51fa\u306b\u6210\u529f\u300d
https:\/\/www.riken.jp\/press\/2022\/20220909_1\/<\/a>
\u6ce83\uff092023\u5e741\u670830\u65e5\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u300c\u30e6\u30fc\u30b0\u30ec\u30ca\u306e\u773c\u70b9\u3092\u3064\u304b\u3055\u3069\u308b\u8272\u7d20\u3092\u540c\u5b9a\u300d
https:\/\/www.riken.jp\/press\/2023\/20230130_2\/<\/a><\/p>\n\n\n\n

\u7814\u7a76\u624b\u6cd5\u3068\u6210\u679c<\/strong>
\u3000\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u306b\u304a\u3044\u3066\u5f93\u6765\u6280\u8853\u3067\u306f\u96e3\u3057\u304b\u3063\u305fAT\u30ea\u30c3\u30c1\u306a\u30b2\u30ce\u30e0\u9818\u57df\u306a\u3069\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b2\u30ce\u30e0\u306e\u7de8\u96c6\u3092\u53ef\u80fd\u306b\u3059\u308b\u305f\u3081\u3001Cas12a RNP\u30d9\u30fc\u30b9\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306e\u5c0e\u5165\u306b\u7740\u624b\u3057\u307e\u3057\u305f\u3002\u5909\u7570\u5c0e\u5165\u306b\u3088\u308a\u3001\u30d1\u30e9\u30df\u30ed\u30f3\u7c92\u5f62\u6210\u4e0d\u5168\u3068\u306a\u308bEgGSL2<\/em>\uff08\u30d1\u30e9\u30df\u30ed\u30f3\u5408\u6210\u9175\u7d20\uff09\u907a\u4f1d\u5b50\u3001\u767d\u8272\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059EgCrtB<\/em>\uff08\u30d5\u30a3\u30c8\u30a8\u30f3\u5408\u6210\u9175\u7d20\uff09\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305fCas12a RNP\u8907\u5408\u4f53\u3092\u7528\u3044\u3001\u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u6cd5[7]<\/sup>\u306b\u3088\u308b\u76f4\u63a5\u5c0e\u5165\u6cd5\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002
\u3000\u305d\u306e\u7d50\u679c\u3001\u4e21\u6a19\u7684\u907a\u4f1d\u5b50\u306b\u304a\u3044\u3066\u3001\u5bfe\u5fdc\u3057\u305f\u8868\u73fe\u578b\u306e\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u5909\u7570\u5c0e\u5165\u682a\u304c\u53d6\u5f97\u3055\u308c\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u52b9\u7387\u3092\u8abf\u3079\u308b\u305f\u3081\u30a2\u30f3\u30d7\u30ea\u30b3\u30f3\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u89e3\u6790[8]<\/sup>\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u300177.2\uff5e94.5\uff05\u306e\u52b9\u7387\u3067\u30e9\u30f3\u30c0\u30e0\u306a\u633f\u5165\uff08Insertion\uff09\u307e\u305f\u306f\u6b20\u5931\uff08Deletion\uff09\u306e\u5909\u7570\uff08InDel\u5909\u7570\uff09\u5c0e\u5165\u304c\u691c\u51fa\u3055\u308c\u3001Cas9 RNP\u8907\u5408\u4f53\u3092\u7528\u3044\u305f\u5834\u5408\u3068\u540c\u7a0b\u5ea6\u306e\u9ad8\u3044\u52b9\u7387\u3067\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u304c\u53ef\u80fd\u3067\u3057\u305f\uff08\u56f31A\uff09\u3002Cas12a RNP\u8907\u5408\u4f53\u3092\u7528\u3044\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3067\u306f\u3001Cas9\u30d9\u30fc\u30b9\u306e\u624b\u6cd5\u306b\u6bd4\u3079\u3001\u9577\u3081\u306e\u6b20\u640d\u5909\u7570\u304c\u5165\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30b2\u30ce\u30e0\u4e0a\u306e\u96e2\u308c\u305f2\u30ab\u6240\u3092\u5207\u65ad\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u9577\u3044\u6b20\u640d\u5909\u7570\u5c0e\u5165\u3084\u3001Cas12a RNP\u8907\u5408\u4f53\u3068\u4e00\u672c\u9396DNA\uff08ssODN\uff08\u4e00\u672c\u9396\u30aa\u30ea\u30b4\u30c7\u30aa\u30ad\u30b7\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09[9]<\/sup>\uff09\u3092\u7528\u3044\u305f\u77ed\u9396DNA\u914d\u5217\u306e\u30ce\u30c3\u30af\u30a4\u30f3\uff08\u633f\u5165\uff09\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001Cas12a RNP\u8907\u5408\u4f53\u3068ssODN\u3092\u7528\u3044\u305fDNA\u914d\u5217\u633f\u5165\u306b\u3088\u308a\u3001\u30b2\u30ce\u30e0\u4e0a\u306e\u7279\u5b9a\u306e\u5869\u57fa\u914d\u5217\u306e\u6b63\u78ba\u306a\u66f8\u304d\u63db\u3048\u304c\u53ef\u80fd\u3067\u3042\u308a\uff08\u56f32\uff09\u3001\u30d1\u30e9\u30df\u30ed\u30f3\u5408\u6210\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5869\u57fa\u914d\u5217\u3092\u66f8\u304d\u63db\u3048\u308b\u3053\u3068\u3067\u3001\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u7f6e\u63db\u306b\u3088\u3063\u3066\u9175\u7d20\u306e\u6a5f\u80fd\u306e\u963b\u5bb3\u3092\u8a98\u5c0e\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n

\"\"<\/p>\n

\u56f31\u3000Cas12a RNP\u8907\u5408\u4f53\u3092\u7528\u3044\u305f\u30e6\u30fc\u30b0\u30ec\u30ca\u306e\u30b2\u30ce\u30e0\u7de8\u96c6<\/p>\n\n\n

\uff08A\uff09\u30a2\u30f3\u30d7\u30ea\u30b3\u30f3\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u89e3\u6790\u306b\u3088\u308b\u3001Cas12a RNP\u8907\u5408\u4f53\u5c0e\u516596\u6642\u9593\u5f8c\u306e\u30e6\u30fc\u30b0\u30ec\u30ca\u7d30\u80de\u96c6\u56e3\u306b\u304a\u3051\u308b\u5404\u6a19\u7684\u30b5\u30a4\u30c8\u3078\u306eInDel\u5909\u7570\u5c0e\u5165\u306e\u52b9\u7387\u3002\uff08B\uff09Cas12a RNP\u8907\u5408\u4f53\u3092\u7528\u3044\u3066\u4f5c\u6210\u3057\u305fEgGSL2<\/em>\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u682a\u306e\u8868\u73fe\u578b\u306e\u4f8b\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u682a\u306b\u306f\u91ce\u751f\u682a\u306b\u898b\u3089\u308c\u308b\u7d30\u80de\u5185\u306e\u7c92\u72b6\u306e\u30d1\u30e9\u30df\u30ed\u30f3\u306e\u751f\u7523\u304c\u898b\u3089\u308c\u306a\u3044\u3002\u30b9\u30b1\u30fc\u30eb\u30d0\u30fc\u306f10\u30de\u30a4\u30af\u30ed\u30e1\u30fc\u30c8\u30eb\uff08\u03bcm\u30011\u03bcm\u306f100\u4e07\u5206\u306e1\u30e1\u30fc\u30c8\u30eb\uff09\u3002\uff08C\uff09Cas12a RNP\u8907\u5408\u4f53\u3092\u7528\u3044\u3066\u4f5c\u6210\u3057\u305fEgcrtB<\/em>\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u682a\u306e\u8868\u73fe\u578b\u306e\u4f8b\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u682a\u306f\u767d\u8272\u5316\u3057\u3066\u3044\u308b\u3002\u30b9\u30b1\u30fc\u30eb\u30d0\u30fc\u306f10\u03bcm\u3002<\/p>\n\n\n

\"\"<\/p>\n

\u56f32\u3000\u30e6\u30fc\u30b0\u30ec\u30ca\u306b\u304a\u3051\u308b\u5869\u57fa\u66f8\u304d\u63db\u3048\u306e\u4f8b<\/p>\n\n\n

\uff08A\uff09\u5869\u57fa\u66f8\u304d\u63db\u3048\u306b\u7528\u3044\u305fssODN\u914d\u5217\u3068\u6a19\u7684\u30b5\u30a4\u30c8\u306e\u6a21\u5f0f\u56f3\u3002\uff08B\uff09Cas12a RNP\u8907\u5408\u4f53\u3092\u7528\u3044\u305f\u5869\u57fa\u66f8\u304d\u63db\u3048\u306e\u52b9\u7387\u3002\uff08C\uff09\u5358\u96e2\u3057\u305f\u5869\u57fa\u66f8\u304d\u63db\u3048\u682a\u306b\u304a\u3051\u308bEgGSL2<\/em>\u907a\u4f1d\u5b50\u5869\u57fa\u66f8\u304d\u63db\u3048\u7b87\u6240\u306e\u78ba\u8a8d\u3002<\/p>\n\n\n\n

\u4eca\u5f8c\u306e\u671f\u5f85<\/strong>
\u3000\u672c\u7814\u7a76\u306b\u3088\u308aCas12a\u3092\u7528\u3044\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u304c\u5229\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u7d50\u679c\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u306b\u304a\u3044\u3066\u3001Cas9\u3067\u306f\u56f0\u96e3\u3067\u3042\u3063\u305fAT\u30ea\u30c3\u30c1\u9818\u57df\u3092\u6a19\u7684\u3068\u3059\u308b\u30b2\u30ce\u30e0\u306e\u7de8\u96c6\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u7cbe\u5bc6\u306a\u5869\u57fa\u66f8\u304d\u63db\u3048\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u30a8\u30f3\u30b8\u30ea\u30cb\u30a2\u30ea\u30f3\u30b0\u3082\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306f\u4eca\u5f8c\u3001\u672c\u7a2e\u306b\u304a\u3051\u308b\u57fa\u790e\u7814\u7a76\u306e\u63a8\u9032\u3084\u6709\u7528\u682a\u306e\u5206\u5b50\u80b2\u7a2e\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002
\u3000\u672c\u7814\u7a76\u306e\u6210\u679c\u306f\u3001\u56fd\u969b\u9023\u5408\u304c\u5b9a\u3081\u305f17\u9805\u76ee\u306e\u300c\u6301\u7d9a\u53ef\u80fd\u306a\u958b\u767a\u76ee\u6a19\uff08SDGs\uff09\u300d\u306e\u3046\u3061\u300c7.\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u307f\u3093\u306a\u306b\u305d\u3057\u3066\u30af\u30ea\u30fc\u30f3\u306b\u300d\u3068\u300c13.\u6c17\u5019\u5909\u52d5\u306b\u5177\u4f53\u7684\u306a\u5bfe\u7b56\u3092\u300d\u7b49\u3078\u306e\u8ca2\u732e\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u8ad6\u6587\u60c5\u5831<\/strong>
\uff1c\u30bf\u30a4\u30c8\u30eb\uff1e
High-efficiency genome editing by Cas12a ribonucleoprotein complex in Euglena gracilis<\/em>
\uff1c\u8457\u8005\u540d\uff1e
Toshihisa Nomura, June-Silk Kim, Marumi Ishikawa, Kengo Suzuki, Keiichi Mochida
\uff1c\u96d1\u8a8c\uff1e
Microbial Biotechnology<\/em>
\uff1cDOI\uff1e
10.1111\/1751-7915.14393<\/a>

\u88dc\u8db3\u8aac\u660e<\/strong>
[1] \u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30b0\u30e9\u30b7\u30ea\u30b9\uff08Euglena gracilis<\/em>\uff09
\u30e6\u30fc\u30b0\u30ec\u30ca\u5c5e\u306e\u5fae\u7d30\u85fb\u985e\u306e\u4e00\u7a2e\u3067\u3001\u6c34\u7530\u3084\u6de1\u6c34\u306e\u6e56\u6cbc\u306a\u3069\u306b\u751f\u80b2\u3057\u3066\u3044\u308b\u3002\u53e4\u304f\u304b\u3089\u751f\u7269\u5b66\u3001\u751f\u5316\u5b66\u306e\u5b9f\u9a13\u6750\u6599\u306b\u5229\u7528\u3055\u308c\u3066\u304d\u305f\u3002\u5c4b\u5185\u5916\u3067\u306e\u5927\u91cf\u57f9\u990a\u6280\u8853\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u591a\u7528\u9014\u3067\u306e\u5229\u7528\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

[2] Cas12a RNP\u8907\u5408\u4f53\u3001AT\u30ea\u30c3\u30c1\u9818\u57df
\u30af\u30e9\u30b92\u30bf\u30a4\u30d7V\u578b\u306b\u5206\u985e\u3055\u308c\u308bCas12a\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u3068\u3001\u6a19\u7684\u914d\u5217\u3092\u542b\u3080CRISPR RNA\uff08crRNA\uff09\u3067\u69cb\u6210\u3055\u308c\u308b\u30ea\u30dc\u6838\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3002Cas12a\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u306e\u5834\u5408\u306f\u3001crRNA\u306e\u307f\u3067\u6d3b\u6027\u306e\u3042\u308bRNP\u8907\u5408\u4f53\u3092\u5f62\u6210\u3067\u304d\u308b\u3002\u6a19\u7684\u914d\u5217\u306e\u8a8d\u8b58\u306b\u5fc5\u8981\u3068\u306a\u308bPAM\u914d\u5217\u306fTTTV\uff08V\u306fA\u3001C\u3001G\u306e\u3069\u308c\u304b\uff09\u3067\u3042\u308b\u305f\u3081AT\u30ea\u30c3\u30c1\u9818\u57df\u3067\u306e\u6a19\u7684\u914d\u5217\u304c\u8a2d\u8a08\u3057\u3084\u3059\u3044\u3002DNA\u306f5’\u7a81\u51fa\u672b\u7aef\u306e\u5f62\u3067\u5207\u65ad\u3055\u308c\u308b\u3002AT\u30ea\u30c3\u30c1\u9818\u57df\u306f\u3001DNA\u3092\u69cb\u6210\u3057A\u3001T\u3001G\u3001C\u306e\u6587\u5b57\u3067\u8868\u3055\u308c\u308b4\u7a2e\u985e\u306e\u5869\u57fa\u306e\u3046\u3061\u3001A\u3068T\u306b\u5bcc\u3080\u30b2\u30ce\u30e0\u9818\u57df\u306e\u3053\u3068\u3002<\/p>\n\n\n\n

[3] \u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853
\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\uff08\u6838\u9178\u5206\u89e3\u9175\u7d20\uff09\u306a\u3069\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u30c4\u30fc\u30eb\u3092\u3001\u914d\u5217\u90e8\u4f4d\u7279\u7570\u7684\u306b\u4f5c\u7528\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u30b2\u30ce\u30e0\u3092\u6539\u5909\u3059\u308b\u6280\u8853\u3002<\/p>\n\n\n\n

[4] \u5869\u57fa\u66f8\u304d\u63db\u3048
\u30b2\u30ce\u30e0\u4e0a\u306e\u7279\u5b9a\u7b87\u6240\u306e\u5869\u57fa\u3092\u66f8\u304d\u63db\u3048\u308b\u907a\u4f1d\u5b50\u5de5\u5b66\u7684\u306a\u624b\u6cd5\u3002<\/p>\n\n\n\n

[5] \u5206\u5b50\u80b2\u7a2e
\u5bfe\u8c61\u3068\u3059\u308b\u751f\u7269\u306e\u30b2\u30ce\u30e0\u306b\u95a2\u3059\u308bDNA\u30ec\u30d9\u30eb\u306e\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u3001\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u3084\u30b2\u30ce\u30e0\u7de8\u96c6\u306a\u3069\u306e\u6280\u8853\u3092\u7528\u3044\u305f\u30b2\u30ce\u30e0\u306e\u6539\u5909\u306b\u3088\u308a\u3001\u76ee\u7684\u306e\u5f62\u8cea\u3092\u6301\u3064\u500b\u4f53\u3092\u4f5c\u51fa\u3059\u308b\u3053\u3068\u3002<\/p>\n\n\n\n

[6] \u6301\u7d9a\u53ef\u80fd\u306a\u958b\u767a\u76ee\u6a19\uff08SDGs\uff09
2015\u5e749\u6708\u306e\u56fd\u9023\u30b5\u30df\u30c3\u30c8\u3067\u63a1\u629e\u3055\u308c\u305f\u300c\u6301\u7d9a\u53ef\u80fd\u306a\u958b\u767a\u306e\u305f\u3081\u306e2030\u30a2\u30b8\u30a7\u30f3\u30c0\u300d\u306b\u3066\u8a18\u8f09\u3055\u308c\u305f\u30012016\u5e74\u304b\u30892030\u5e74\u307e\u3067\u306e\u56fd\u969b\u76ee\u6a19\u3002\u6301\u7d9a\u53ef\u80fd\u306a\u4e16\u754c\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306e17\u306e\u30b4\u30fc\u30eb\u3001169\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u304b\u3089\u69cb\u6210\u3055\u308c\u3001\u767a\u5c55\u9014\u4e0a\u56fd\u306e\u307f\u306a\u3089\u305a\u3001\u5148\u9032\u56fd\u81ea\u8eab\u304c\u53d6\u308a\u7d44\u3080\u30e6\u30cb\u30d0\u30fc\u30b5\u30eb\uff08\u666e\u904d\u7684\uff09\u306a\u3082\u306e\u3067\u3042\u308a\u3001\u65e5\u672c\u3068\u3057\u3066\u3082\u7a4d\u6975\u7684\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\uff08\u5916\u52d9\u7701\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u304b\u3089\u4e00\u90e8\u6539\u5909\u3057\u3066\u8ee2\u8f09\uff09\u3002SDGs\u306fSustainable Development Goals\u306e\u7565\u3002<\/p>\n\n\n\n

[7] \u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u6cd5
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[8] \u30a2\u30f3\u30d7\u30ea\u30b3\u30f3\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u89e3\u6790
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[9] ssODN\uff08\u4e00\u672c\u9396\u30aa\u30ea\u30b4\u30c7\u30aa\u30ad\u30b7\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09
\u30c9\u30ca\u30fcDNA\u3068\u3057\u3066RNP\u8907\u5408\u4f53\u3068\u4e00\u7dd2\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u76f8\u540c\u6027\u4fee\u5fa9\u6a5f\u69cb\u306b\u3088\u308b\u30ce\u30c3\u30af\u30a4\u30f3\u3084\u5869\u57fa\u66f8\u304d\u63db\u3048\u304c\u3067\u304d\u308b\u3002

\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7<\/strong>
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\u7814\u7a76\u54e1\uff08\u7814\u7a76\u5f53\u6642\uff09 \u91ce\u6751\u4fca\u5c1a\uff08\u30ce\u30e0\u30e9\u30fb\u30c8\u30b7\u30d2\u30b5\uff09
\uff08\u79d1\u6280\u30cf\u30d6\u7523\u9023\u672c\u90e8 \u30d0\u30c8\u30f3\u30be\u30fc\u30f3\u7814\u7a76\u63a8\u9032\u30d7\u30ed\u30b0\u30e9\u30e0\u3000\u85fb\u985e\u8cc7\u6e90\u30a2\u30c3\u30d7\u30b5\u30a4\u30af\u30eb\u7814\u7a76\u30c1\u30fc\u30e0\u3000\u7814\u7a76\u54e1\uff08\u7814\u7a76\u5f53\u6642\uff09\u3001\u73fe\u3000\u5c71\u5f62\u5927\u5b66\u8fb2\u5b66\u90e8\u3000\u51c6\u6559\u6388\u3001\u74b0\u5883\u8cc7\u6e90\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3000\u30d0\u30a4\u30aa\u751f\u7523\u60c5\u5831\u7814\u7a76\u30c1\u30fc\u30e0\u3000\u5ba2\u54e1\u4e3b\u7ba1\u7814\u7a76\u54e1\uff09
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\u79d1\u6280\u30cf\u30d6\u7523\u9023\u672c\u90e8\u3000\u30d0\u30c8\u30f3\u30be\u30fc\u30f3\u7814\u7a76\u63a8\u9032\u30d7\u30ed\u30b0\u30e9\u30e0\u3000\u5fae\u7d30\u85fb\u985e\u751f\u7523\u5236\u5fa1\u6280\u8853\u7814\u7a76\u30c1\u30fc\u30e0
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\u79d1\u6280\u30cf\u30d6\u7523\u9023\u672c\u90e8\u3000\u30d0\u30c8\u30f3\u30be\u30fc\u30f3\u7814\u7a76\u63a8\u9032\u30d7\u30ed\u30b0\u30e9\u30e0\u3000\u85fb\u985e\u8cc7\u6e90\u30a2\u30c3\u30d7\u30b5\u30a4\u30af\u30eb\u7814\u7a76\u30c1\u30fc\u30e0
\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\u3000 \u9234\u6728\u5065\u543e\uff08\u30b9\u30ba\u30ad\u30fb\u30b1\u30f3\u30b4\uff09
\uff08\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\u3000\u30a8\u30b0\u30bc\u30af\u30c6\u30a3\u30d6\u30d5\u30a7\u30ed\u30fc\uff09

\u7814\u7a76\u652f\u63f4<\/strong>
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<\/p>\n\n\n\n

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