{"id":24959,"date":"2022-02-03T15:00:21","date_gmt":"2022-02-03T06:00:21","guid":{"rendered":"https:\/\/www.euglena.jp\/news\/?p=24959"},"modified":"2022-11-14T11:58:03","modified_gmt":"2022-11-14T02:58:03","slug":"20220203","status":"publish","type":"post","link":"https:\/\/www.euglena.jp\/news\/20220203\/","title":{"rendered":"\u65b0\u305f\u306a\u5316\u7ca7\u54c1\u539f\u6599\u3068\u3057\u3066\u300c\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u300d\u3092\u958b\u767a"},"content":{"rendered":"

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\n\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u304c\u30d2\u30c8\u306e\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u3001\u8868\u76ae\u89d2\u5316\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3057\u3001
\n\u8001\u5316\u3057\u305f\u7d30\u80de\u3092\u9664\u53bb\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u3059\u7814\u7a76\u7d50\u679c\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f<\/p>\n

\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca<\/p>\n

\u3000<\/strong>\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u672c\u793e\uff1a\u6771\u4eac\u90fd\u6e2f\u533a\u3001\u4ee3\u8868\u53d6\u7de0\u5f79\u793e\u9577\uff1a\u51fa\u96f2\u5145\uff09\u306f\u3001\u5fae\u7d30\u85fb\u985e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u548c\u540d\uff1a\u30df\u30c9\u30ea\u30e0\u30b7\u3001\u4ee5\u4e0b\u300c\u30e6\u30fc\u30b0\u30ec\u30ca\u300d\uff09\u3092\u7528\u3044\u305f\u65b0\u305f\u306a\u5316\u7ca7\u54c1\u539f\u6599\u3068\u3057\u3066\u300c\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u300d\u3092\u898f\u683c\u5316\u203b1<\/sup>\u3057\u305f\u3053\u3068\u3092\u304a\u77e5\u3089\u305b\u3057\u307e\u3059\u3002<\/p>\n

\"\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\"<\/p>\n

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\n\u203b1 \u539f\u6599\u3068\u3057\u3066\u306e\u54c1\u8cea\u57fa\u6e96\u3092\u5b9a\u3081\u308b\u3053\u3068
\n\u203b2 \u30d6\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306e\u7565\u3067\u3042\u308a\u3001\u5316\u7ca7\u54c1\u3067\u4fdd\u6e7f\u5264\u3001\u9632\u8150\u5264\u306a\u3069\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u308b\u591a\u4fa1\u30a2\u30eb\u30b3\u30fc\u30eb
\n\u203b3 \u76ae\u819a\u306e\u771f\u76ae\u306b\u5b58\u5728\u3059\u308b\u7dda\u7dad\u82bd\u7d30\u80de\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3001\u30a8\u30e9\u30b9\u30c1\u30f3\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306a\u3069\u306e\u7d30\u80de\u5916\u57fa\u8cea\u3068\u547c\u3070\u308c\u308b\u3001\u30cf\u30ea\u3084\u5f3e\u529b\u306e\u7dad\u6301\u306b\u5fc5\u8981\u306a\u7269\u8cea\u3092\u7523\u751f\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b
\n\u203b4 \u76ae\u819a\u306e\u6700\u3082\u5916\u5074\u306b\u3042\u308b\u8868\u76ae\u306f\u3001\u5916\u754c\u306e\u7d30\u83cc\u306a\u3069\u306e\u4fb5\u5165\u304b\u3089\u76ae\u819a\u3092\u4fdd\u8b77\u3057\u3001\u4f53\u5185\u306e\u6c34\u5206\u304c\u4f53\u5916\u306b\u904e\u5ea6\u306b\u84b8\u6563\u3059\u308b\u306e\u3092\u9632\u3050\u305f\u3081\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u6301\u3064<\/span><\/p>\n

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\n\u3000<\/strong>\u30d2\u30c8\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u3092\u6dfb\u52a0\u3057\u3001\u57f9\u990a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u306f\u3001\u4f55\u3082\u6dfb\u52a0\u3057\u3066\u306a\u3044\u3082\u306e\uff080%\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306b\u30d2\u30c8\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u5897\u6b96\u3092\u6709\u610f\u306b\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u304c\u5897\u6b96\u3059\u308b\u3053\u3068\u3067\u3001\u30cf\u30ea\u3084\u5f3e\u529b\u304c\u7dad\u6301\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n

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\n***p<0.001\u3001vs 0%\u3001t\u691c\u5b9a\uff08\u30dc\u30f3\u30d5\u30a7\u30ed\u30fc\u30cb\u88dc\u6b63\uff09\u3001PC\u306f\u30dd\u30b8\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/span><\/p>\n

 <\/p>\n

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\n\u3000<\/strong>\u30d2\u30c8\u8868\u76ae\u89d2\u5316\u7d30\u80de\u306b\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u3092\u6dfb\u52a0\u3057\u3001\u57f9\u990a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u306f\u3001\u4f55\u3082\u6dfb\u52a0\u3057\u3066\u306a\u3044\u3082\u306e\uff080%\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306b\u30d2\u30c8\u8868\u76ae\u89d2\u5316\u7d30\u80de\u306e\u5897\u6b96\u3092\u6709\u610f\u306b\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\uff08\u56f32\uff09\u3002\u8868\u76ae\u89d2\u5316\u7d30\u80de\u306e\u5897\u6b96\u304c\u4fc3\u9032\u3055\u308c\u308b\u3068\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\uff08\u65b0\u9673\u4ee3\u8b1d\uff09\u306b\u3088\u308a\u53e4\u3044\u89d2\u8cea\u304c\u9664\u53bb\u3055\u308c\u76ae\u819a\u306e\u5065\u5eb7\u3092\u4fdd\u3064\u3053\u3068\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n

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\n***p<0.001\u3001**p<0.01\u3001vs 0%\u3001t\u691c\u5b9a\uff08\u30dc\u30f3\u30d5\u30a7\u30ed\u30fc\u30cb\u88dc\u6b63\uff09\u3001PC\u306f\u30dd\u30b8\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/span><\/p>\n

 <\/p>\n

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\n\u3000<\/strong>GLS-1\u907a\u4f1d\u5b50\u306f\u8001\u5316\u7d30\u80de\u306e\u751f\u5b58\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u203b5<\/sup>\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u89d2\u5316\u7d30\u80de\u306b\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u3092\u6dfb\u52a0\u3057\u57f9\u990a\u3059\u308b\u3068\u3001\u4f55\u3082\u6dfb\u52a0\u305b\u305a\u57f9\u990a\u3057\u305f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3001GLS-1\u306e\u767a\u73fe\u304c\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306b\u3001\u7279\u306b5%\u6dfb\u52a0\u7fa4\u3067\u306f\u6709\u610f\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\uff08\u56f33\uff09\u3002\u3055\u3089\u306b\u3001\u904e\u9178\u5316\u6c34\u7d20\u306b\u3088\u308b\u51e6\u7406\u203b6<\/sup>\u3067\u89d2\u5316\u7d30\u80de\u306e\u8001\u5316\u3092\u4fc3\u9032\u3057\u3001\u305d\u3053\u306b\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u3092\u6dfb\u52a0\u3057\u3066\u57f9\u990a\u3059\u308b\u3068\u3001\u4f55\u3082\u6dfb\u52a0\u305b\u305a\u57f9\u990a\u3057\u305f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3001\u901a\u5e38\u306e\u89d2\u5316\u7d30\u80de\u3067\u306f\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u306e\u6dfb\u52a0\u306b\u3088\u308a\u7d30\u80de\u5897\u6b96\u304c\u4fc3\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u8001\u5316\u7d30\u80de\u3067\u306f\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u3092\u6dfb\u52a0\u3057\u3066\u3082\u7d30\u80de\u5897\u6b96\u306f\u4fc3\u3055\u308c\u305a\u3001\u6709\u610f\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\uff08\u56f34\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u3088\u308a\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u30a8\u30ad\u30b9EX\u304c\u8001\u5316\u7d30\u80de\u306e\u9664\u53bb\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002
\n\u203b5 GLS-1\u907a\u4f1d\u5b50\u306f\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u4ee3\u8b1d\u306b\u95a2\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308b\u304c\u3001\u8001\u5316\u7d30\u80de\u306e\u751f\u5b58\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u306e\u7570\u5e38\u306b\u8d77\u56e0\u3057\u3066\u3001\u8001\u5316\u7d30\u80de\u5185\u306f\u9178\u6027\u306b\u50be\u3044\u3066\u304a\u308a\u3001GLS-1\u304c\u904e\u5270\u306b\u50cd\u3044\u3066\u4e2d\u548c\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u3002\u6b63\u5e38\u7d30\u80de\u304a\u3088\u3073\u8001\u5316\u7d30\u80de\u306b\u304a\u3051\u308bGLS-1\u963b\u5bb3\u306e\u5f71\u97ff\u306e\u691c\u8a0e\u7d50\u679c\u304b\u3089\u3001GLS-1\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u8001\u5316\u7d30\u80de\u3092\u9078\u629e\u7684\u306b\u6b7b\u6ec5\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002
\nJohmura Y, Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M. Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders. Science. 2021 Jan 15;371(6526):265-270. doi: 10.1126\/science.abb5916. PMID: 33446552.
\n\u203b6 Ido Y, Duranton A, Lan F, Weikel KA, Breton L, Ruderman NB. Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes. PLoS One. 2015 Feb 3;10(2):e0115341. doi: 10.1371\/journal.pone.0115341. PMID: 25647160; PMCID: PMC4315597.<\/span><\/p>\n

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\n*p<0.05\u3001 t\u691c\u5b9a\uff08\u30dc\u30f3\u30d5\u30a7\u30ed\u30fc\u30cb\u88dc\u6b63\uff09vs \u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/span><\/p>\n

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