\n\u203b1\u3000\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\uff1a\u85fb\u985e\u3084\u30ad\u30ce\u30b3\u985e\u3001\u690d\u7269\u306b\u542b\u307e\u308c\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u304c3\uff5e20\u500b\u7a0b\u5ea6\u03b2-1,3\u7d50\u5408\u3057\u305f\u591a\u7cd6\u4f53\uff08\u30b0\u30eb\u30ab\u30f3\uff09<\/span>
\n\u203b2\u3000\u514d\u75ab\u53d7\u5bb9\u4f53\uff1a\u514d\u75ab\u7d30\u80de\u306e\u7d30\u80de\u819c\u3001\u7d30\u80de\u8cea\u307e\u305f\u306f\u6838\u5185\u306b\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u7279\u7570\u7684\u306a\u7269\u8cea\uff08\u30ea\u30ac\u30f3\u30c9\uff09\u3068\u7d50\u5408\u3057\u3066\u514d\u75ab\u53cd\u5fdc\u3092\u958b\u59cb\u3055\u305b\u308b<\/span><\/p>\n
\u25a0\u7814\u7a76\u306e\u80cc\u666f\u3068\u76ee\u7684 \u25a0\u7814\u7a76\u306e\u5185\u5bb9\u3068\u7d50\u679c \u56f31\u3000\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u6d3b\u6027\u5316<\/p>\n CD3 antibody\uff0bCD28 antibody\u3092\u30dd\u30b8\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u8a2d\u5b9a\u3057\u3066\u3044\u308b<\/span><\/p>\n \u3000\u3055\u3089\u306b\u3001\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u5206\u5b50\u52d5\u529b\u5b66\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u3063\u3066\u3001\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u3068\u514d\u75ab\u53d7\u5bb9\u4f53\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u306f\u3001\u514d\u75ab\u53d7\u5bb9\u4f53CD28\u3068\u53ef\u9006\u7684\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\uff08\u56f32A\uff09\u3002\u305d\u306e\u7d50\u5408\u9818\u57df\u306f\u3001\u901a\u5e38\u3001T\u7d30\u80de\u3092\u523a\u6fc0\u3059\u308b\u6297\u539f\u63d0\u793a\u7d30\u80de\u5074\u306e\u53d7\u5bb9\u4f53\u3067\u3042\u308bCD80\u304a\u3088\u3073CD86\u304c\u514d\u75ab\u53d7\u5bb9\u4f53CD28\u306b\u7d50\u5408\u3059\u308b\u9818\u57df\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059\u3002 \u56f32\u3000\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u3068\u514d\u75ab\u53d7\u5bb9\u4f53CD28\u3068\u306e\u76f8\u4e92\u4f5c\u7528<\/p>\n \u7d2b\u8272\u306e\u8868\u9762\u306f\u30b0\u30eb\u30ab\u30f3\u306e\u6fc3\u5ea6\u304c\u5468\u56f2\u306e\u6fc3\u5ea6\u306e30\u500d\u3092\u8d85\u3048\u308b\u9818\u57df\u3092\u8868\u3059<\/span> \u3000\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001\u03b2-1,3-\u30b0\u30eb\u30ab\u30f3\u304c\u514d\u75ab\u53d7\u5bb9\u4f53CD28\u306b\u7d50\u5408\u3057\u3001T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3057\u3066\u3001\u514d\u75ab\u6a5f\u80fd\u3092\u523a\u6fc0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u65b0\u305f\u306b\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n \u3000\u4eca\u5f8c\u3082\u3001\u3053\u306e\u3088\u3046\u306a\u57fa\u790e\u7814\u7a76\u3092\u306f\u3058\u3081\u3001\u03b2-1,3-\u30b0\u30eb\u30ab\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30d1\u30e9\u30df\u30ed\u30f3\u3067\u306e\u7814\u7a76\u3084\u3001\u514d\u75ab\u30e1\u30ab\u30cb\u30ba\u30e0\u306a\u3069\u30d2\u30c8\u306e\u751f\u4f53\u6a5f\u80fd\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u5b9f\u65bd\u3057\u3066\u3044\u304f\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n \uff1c\u5fae\u7d30\u85fb\u985e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u548c\u540d\uff1a\u30df\u30c9\u30ea\u30e0\u30b7\uff09\u306b\u3064\u3044\u3066\uff1e \uff1c\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\u306b\u3064\u3044\u3066\uff1e \u4ee5\u4e0a<\/p>\n \u2015\u304a\u554f\u3044\u5408\u308f\u305b\u5148\u2015 \u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u304c\u3001\u514d\u75ab\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3042\u308bT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f \u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca \u3000\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u672c\u793e\uff1a\u6771\u4eac\u90fd\u6e2f\u533a\u3001\u4ee3\u8868\u53d6\u7de0\u5f79\u793e\u9577\uff1a\u51fa\u96f2\u5145\uff09\u306f\u3001\u7c73\u56fd\u306e\u30ab\u30f3\u30b6\u30b9\u5dde\u7acb\u5927\u5b66Jeffrey […]<\/p>\n","protected":false},"author":12,"featured_media":22486,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[10],"acf":[],"_links":{"self":[{"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/posts\/22485"}],"collection":[{"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/comments?post=22485"}],"version-history":[{"count":15,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/posts\/22485\/revisions"}],"predecessor-version":[{"id":22724,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/posts\/22485\/revisions\/22724"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/media\/22486"}],"wp:attachment":[{"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/media?parent=22485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/categories?post=22485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/tags?post=22485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n\u3000<\/strong>\u03b2-1,3-\u30b0\u30eb\u30ab\u30f3\u306f\u3001\u03b2-1,3-\u30b0\u30ea\u30b3\u30b7\u30c9\u7d50\u5408\u203b3\u306b\u3066\u9023\u306a\u3063\u305f\u30b0\u30eb\u30b3\u30fc\u30b9\u3092\u69cb\u6210\u7cd6\u3068\u3059\u308b\u591a\u7cd6\u3067\u3059\u3002\u03b2-1,3-\u30b0\u30eb\u30ab\u30f3\u306b\u306f\u3001\u7d30\u83cc\u3084\u771f\u83cc\u3001\u9175\u6bcd\u305d\u3057\u3066\u5927\u9ea6\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u7531\u6765\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5fae\u7d30\u85fb\u985e\u30e6\u30fc\u30b0\u30ec\u30ca\u7279\u6709\u306e\u6210\u5206\u3067\u3042\u308b\u30d1\u30e9\u30df\u30ed\u30f3\u3082\u03b2-1,3-\u30b0\u30eb\u30ab\u30f3\u306e\u4e00\u7a2e\u3067\u3059\u3002
\n\u3000<\/strong>\u3053\u308c\u307e\u3067\u306b\u3001\u03b2-1,3-\u30b0\u30eb\u30ab\u30f3\u3092\u542b\u3080\u03b2-\u30b0\u30eb\u30ab\u30f3\u304c\u3001\u514d\u75ab\u53d7\u5bb9\u4f53\u306eCR3\u3084Dectin-1\u3001TLR-2\u306a\u3069\u3092\u4ecb\u3057\u3066\u3001\u81ea\u7136\u514d\u75ab\u203b4<\/sup>\u7cfb\u306b\u3088\u3063\u3066\u8a8d\u8b58\u3055\u308c\u3001\u514d\u75ab\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7a2e\u3005\u306e\u514d\u75ab\u53d7\u5bb9\u4f53\u304c\u03b2-1,3-\u30b0\u30eb\u30ab\u30f3\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3001\u4e8b\u524d\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7d50\u679c\u3067\u3001\u03b2-\u30b0\u30eb\u30ab\u30f3\u306e\u306a\u304b\u3067\u3082\u4eca\u56de\u306e\u7814\u7a76\u76ee\u7684\u306b\u9069\u3057\u3066\u3044\u308b\u3068\u60f3\u5b9a\u3055\u308c\u305f\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u3092\u5bfe\u8c61\u3068\u3057\u3066\u7814\u7a76\u3057\u307e\u3057\u305f\u3002
\n\u203b3\u3000\u30b0\u30ea\u30b3\u30b7\u30c9\u7d50\u5408\uff1a\u70ad\u6c34\u5316\u7269\uff08\u7cd6\uff09\u5206\u5b50\u3068\u5225\u306e\u6709\u6a5f\u5316\u5408\u7269\u3068\u304c\u8131\u6c34\u7e2e\u5408\u3057\u3066\u5f62\u6210\u3059\u308b\u5171\u6709\u7d50\u5408<\/span>
\n\u203b4\u3000\u81ea\u7136\u514d\u75ab\uff1a\u514d\u75ab\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u3001\u4fb5\u5165\u3057\u3066\u304d\u305f\u75c5\u539f\u4f53\u3084\u7570\u5e38\u306b\u306a\u3063\u305f\u81ea\u5df1\u306e\u7d30\u80de\u3092\u3044\u3061\u65e9\u304f\u611f\u77e5\u3057\u3001\u305d\u308c\u3092\u6392\u9664\u3059\u308b\u4ed5\u7d44\u307f<\/span><\/p>\n
\n\u3000<\/strong>T\u30ea\u30f3\u30d1\u82bd\u7403\u7d30\u80de\u203b5<\/sup>\u306b\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\uff08\u56f31\u4e2d\u3067\u306fOG\u3068\u8868\u8a18\uff09\u3092\u6dfb\u52a0\u3057\u3066\u57f9\u990a\u3057\u305f\u3068\u3053\u308d\u3001\u7279\u306b\u6297CD3\u203b6<\/sup>\u6297\u4f53\u306e\u5b58\u5728\u4e0b\uff08\u514d\u75ab\u7cfb\u304c\u653b\u6483\u3059\u3079\u304d\u6297\u539f\u3092\u63d0\u793a\u3057\u3001T\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u6297\u539f\u63d0\u793a\u7d30\u80de\u306f\u3001CD3\u3068CD28\u3092\u4ecb\u3057\u3066T\u7d30\u80de\u306b\u30b7\u30b0\u30ca\u30eb\u3092\u9001\u308b\u305f\u3081\u3001CD3\u3092\u523a\u6fc0\u3059\u308b\u6297\u4f53\u3092\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u3068\u5408\u308f\u305b\u3066\u6dfb\u52a0\u3057\u3066\u3044\u308b\u72b6\u614b\uff09\u3067\u3001T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u793a\u3059\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-2\u3001IFN-\u03b3\u3001TNF-\u03b1\uff09\u306emRNA\u203b7<\/sup>\u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08\u56f31\uff09\u3002
\n\u203b5\u3000\u30ea\u30f3\u30d1\u82bd\u7403\u7d30\u80de\uff1a\u4e00\u822c\u306b\u6210\u719f\u30ea\u30f3\u30d1\u7403\u306b\u5206\u5316\u3059\u308b\u672a\u6210\u719f\u306a\u7d30\u80de<\/span>
\n\u203b6\u3000CD3\uff1a\u514d\u75ab\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3042\u308bT\u7d30\u80de\u53d7\u5bb9\u4f53\u306e\u69cb\u6210\u6210\u5206\u3067\u3042\u308a\u3001T\u7d30\u80de\u306e\u30de\u30fc\u30ab\u30fc\uff08\u76ee\u5370\uff09\u3068\u3057\u3066\u6700\u3082\u591a\u7528\u3055\u308c\u308b<\/span>
\n\u203b7\u3000mRNA(messenger RNA)\uff1aRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306b\u3088\u3063\u3066\u907a\u4f1d\u5b50(DNA)\u304b\u3089 \u8ee2\u5199\u3055\u308c\u305f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u914d\u5217\u60c5\u5831\u3092\u30b3\u30fc\u30c9\u3059\u308bRNA<\/span><\/p>\n![\"\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u6d3b\u6027\u5316\"](\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2021\/04\/c0c76df8e144e509f19713eeab5b05aa.jpg\")
<\/p>\n
\n\u3000<\/strong>\u6bd4\u8f03\u306e\u305f\u3081\u306b\u3001\u03b2-\u30b0\u30eb\u30ab\u30f3\u306e\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\u203b8<\/sup>\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308bDectin-1\u3068\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u78ba\u8a8d\u3057\u305f\u3068\u3053\u308d\u3001\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u3068Dectin-1\u306e\u7d50\u5408\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\uff08\u56f32B\uff09\u3002
\n\u3000<\/strong>\u3053\u308c\u3089\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306f\u3001\u4eca\u56de\u65b0\u305f\u306b\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u3068\u306e\u7d50\u5408\u304c\u78ba\u8a8d\u3055\u308c\u305fCD28\u304c\u3001\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u306b\u5bfe\u3057\u3066Dectin-1\u3068\u540c\u69d8\u306e\u89aa\u548c\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u672c\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u306f\u3001\u540c\u3058\u90e8\u4f4d\u306b\u5bfe\u3059\u308b\u03b1-1,4-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u203b9<\/sup>\u306e\u89aa\u548c\u6027\u304c\u306f\u308b\u304b\u306b\u4f4e\u304b\u3063\u305f\u305f\u3081\u3001\u03b2-1,3-\u30aa\u30ea\u30b4\u30b0\u30eb\u30ab\u30f3\u306b\u7279\u7570\u7684\u306a\u7d50\u5408\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n\u203b8\u3000\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\uff1a\u81ea\u7136\u514d\u75ab\u306b\u95a2\u3059\u308b\u7d30\u80de\u306b\u5b58\u5728\u3057\u3001\u75c5\u539f\u4f53\u306a\u3069\u306e\u7570\u7269\u3092\u8a8d\u8b58\u3059\u308b\u6a5f\u80fd\u3092\u3082\u3064\u53d7\u5bb9\u4f53<\/span>
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