\n\u3000<\/strong>\u306a\u304a\u3001\u4eca\u56de\u306e\u7814\u7a76\u7d50\u679c\u306f\u30012020\u5e742\u67087\u65e5\u4ed8\u3067\u30cd\u30a4\u30c1\u30e3\u30fc\u30fb\u30ea\u30b5\u30fc\u30c1\u306b\u3088\u3063\u3066\u520a\u884c\u3055\u308c\u3066\u3044\u308b\u30aa\u30f3\u30e9\u30a4\u30f3\u306e\u5b66\u8853\u30b8\u30e3\u30fc\u30ca\u30eb\u300eScientific Reports\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\uff08https:\/\/nature.com\/articles\/s41598-020-58911-w<\/a>\uff09\u3002
\n\u203b1\u3000\u8868\u76ae\u57fa\u5e95\u5c64\u306b\u3042\u308b\u8272\u7d20\u7d30\u80de\uff08\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\uff09 \u5185\u306e\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u3068\u547c\u3070\u308c\u308b\u5c0f\u5668\u5b98\u306b\u304a\u3044\u3066\u751f\u6210\u3055\u308c\u308b\u8272\u7d20\u3002
\n\u203b2\u3000\u30de\u30a4\u30af\u30edRNA\u306f21\u301c25\u5869\u57fa\u304b\u3089\u6210\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u306a\u3044\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306e\u4e00\u7a2e\u3002\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u6a5f\u80fd\u306a\u3069\u3092\u6709\u3057\uff0c\u4eba\u9593\u306e\u4f53\u5185\u306b\u306f2,000\u7a2e\u985e\u4ee5\u4e0a\u304c\u5b58\u5728\u3059\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n
\u25a0\u7814\u7a76\u306e\u80cc\u666f\u3068\u76ee\u7684 \u25a0\u7814\u7a76\u5185\u5bb9\u3068\u7d50\u679c \u2461miRNA-141-3p\u3068miRNA-200a-3p\u3092\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3059\u308b\u3068\uff0c\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u6291\u5236\u3055\u308c\u307e\u3057\u305f \u203bmiR-NC :\u30d2\u30c8\u3001\u30de\u30a6\u30b9\u307e\u305f\u306f\u30e9\u30c3\u30c8\u306e\u3044\u304b\u306a\u308b\u907a\u4f1d\u5b50\u3082\u6a19\u7684\u3068\u3057\u306a\u3044\u72ec\u81ea\u306e\u914d\u5217\u306b\u30c7\u30b6\u30a4\u30f3\u3055\u308c\u305f\u30cd\u30ac\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u8a66\u85ac\u3067\u3042\u308a\u3001miRNA\u306e\u5c0e\u5165\u8a66\u9a13\u306e\u969b\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3002 \u2462miRNA-141-3p\u3068miRNA-200a-3p\u306e\u5c0e\u5165\u306b\u3088\u308a\u3001\uff13\u6b21\u5143\u30d2\u30c8\u76ae\u819a\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3082\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u6291\u5236\u3055\u308c\u307e\u3057\u305f \uff1c\u56fd\u7acb\u5927\u5b66\u6cd5\u4eba\u4e09\u91cd\u5927\u5b66\u306b\u3064\u3044\u3066\uff1e \uff1c\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\u306b\u3064\u3044\u3066\uff1e \u4ee5\u4e0a<\/p>\n \u2015\u5831\u9053\u95a2\u4fc2\u8005\u304a\u554f\u3044\u5408\u308f\u305b\u5148\u2015<\/strong> \u808c\u7d30\u80de\u306b\u304a\u3051\u308b\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306b\u95a2\u4e0e\u3059\u308b\u65b0\u305f\u306a\u30de\u30a4\u30af\u30edRNA\u3092\u767a\u898b\u3057\u3001\u305d\u308c\u3089\u306e\u5c0e\u5165\u306b\u3088\u308b\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u6291\u5236\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f \uff5e\u5316\u7ca7\u54c1\u958b\u767a\u3067\u306e\u6d3b\u7528\u306b\u671f\u5f85\uff5e \u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca \u56fd\u7acb\u5927\u5b66\u6cd5\u4eba\u4e09\u91cd\u5927\u5b66 \u3000\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u672c\u793e\uff1a […]<\/p>\n","protected":false},"author":10,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[8],"acf":[],"_links":{"self":[{"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/posts\/18285"}],"collection":[{"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/comments?post=18285"}],"version-history":[{"count":10,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/posts\/18285\/revisions"}],"predecessor-version":[{"id":18301,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/posts\/18285\/revisions\/18301"}],"wp:attachment":[{"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/media?parent=18285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/categories?post=18285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euglena.jp\/news\/wp-json\/wp\/v2\/tags?post=18285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n\u3000<\/strong>\u76ae\u819a\u306e\u30b7\u30df\u306a\u3069\u306e\u8272\u7d20\u6c88\u7740\u306f\u3001\u30db\u30eb\u30e2\u30f3\u306e\u7570\u5e38\u3084\u7d2b\u5916\u7dda\u3001\u76ae\u819a\u5c40\u6240\u306e\u708e\u75c7\u306a\u3069\u306b\u3088\u308a\u904e\u5270\u306b\u751f\u6210\u3055\u308c\u305f\u30e1\u30e9\u30cb\u30f3\u304c\u3001\u76ae\u819a\u5185\u306b\u6c88\u7740\u3057\u305f\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u3082\u76ae\u819a\u306e\u8272\u7d20\u6c88\u7740\u3092\u4e88\u9632\u3001\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u6291\u5236\u3059\u308b\u30d3\u30bf\u30df\u30f3\uff23\u3092\u7d4c\u53e3\u6442\u53d6\u3059\u308b\u65b9\u6cd5\u3084\u3001\u30d3\u30bf\u30df\u30f3\uff23\u3001\u30b3\u30a6\u30b8\u9178\u3001\u30cf\u30a4\u30c9\u30ed\u30ad\u30ce\u30f3\u3092\u76ae\u819a\u306b\u5c40\u6240\u5857\u5e03\u3059\u308b\u65b9\u6cd5\u306a\u3069\u304c\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u4e00\u65b9\u3001\u6a19\u7684\u907a\u4f1d\u5b50 \u203b3<\/sup><\/span>\u306e\u767a\u73fe\u3092\u8abf\u6574\u3059\u308b\u6a5f\u80fd\u306a\u3069\u3092\u6709\u3059\u308bmiRNA\u3092\u5229\u7528\u3057\u3066\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u6291\u5236\u3057\u3001\u30b7\u30df\u306a\u3069\u306e\u8272\u7d20\u6c88\u7740\u3092\u4e88\u9632\u3001\u6539\u5584\u3059\u308b\u6280\u8853\u958b\u767a\u304c\u671b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002
\n\u3000<\/strong>\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u6574\u3059\u308b\u6a5f\u80fd\u306a\u3069\u3092\u6709\u3059\u308bmiRNA\u306e\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306b\u304a\u3051\u308b\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u6291\u5236\u5264\u3001\u7f8e\u767d\u5264\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u6291\u5236\u5264\u3084\u305d\u308c\u3089\u3092\u542b\u3080\u5316\u7ca7\u54c1\u306e\u958b\u767a\u306a\u3069\u306b\u6d3b\u7528\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002
\n\u203b3\u3000\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3002<\/span><\/p>\n
\n\u2460\u7d2b\u5916\u7dda\u3092\u7167\u5c04\u3057\u305f\u969b\u306b\u8d77\u3053\u308b\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306b\u95a2\u4e0e\u3059\u308bmiRNA\u3092\u767a\u898b\u3057\u307e\u3057\u305f
\n\u3000<\/strong>\u30de\u30a6\u30b9\u7531\u6765\u306e\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8 \u203b4<\/sup><\/span>\u3092\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08\u03b1-MSH\uff09 \u203b5<\/sup><\/span>\u3067\u523a\u6fc0\u3059\u308b\u3053\u3068\u3067\u3001\u7d2b\u5916\u7dda\u3092\u7167\u5c04\u3057\u305f\u969b\u306e\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u904e\u7a0b\u3092\u518d\u73fe\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u3053\u306e\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u904e\u7a0b\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u8abf\u6574\u3059\u308b2\u7a2e\uff08miRNA-141-3p\u3068miRNA-200a-3p\uff09\u306emiRNA\u3092\u65b0\u3057\u304f\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u306e\uff12\u7a2e\u306emiRNA\u306f\u3001\u03b1-MSH\u3067\u523a\u6fc0\u3059\u308b\u3068\u7d30\u80de\u5185\u3067\u305d\u306e\u91cf\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002
\n\u203b4\u3000\u8868\u76ae\u57fa\u5e95\u5c64\u306b\u3042\u308b\u30e1\u30e9\u30cb\u30f3\u304c\u751f\u6210\u3055\u308c\u308b\u8272\u7d20\u7d30\u80de\u3002
\n\u203b5\u3000\u4e0b\u5782\u4f53\u524d\u8449\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u7a2e\u3002<\/span><\/p>\n![\"\u56f31\"](\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2020\/03\/795316b92fc766b0181f6fef074f03fa-1.png\")
![\"\u56f32\"](\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2020\/03\/2b530e80c7d0de90885e285c5d798063.png\")
<\/p>\n
\n\u3000<\/strong>\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3092\u03b1-MSH\u3067\u523a\u6fc0\u3059\u308b\u3068\u524d\u8ff0\u3057\u305f\uff12\u7a2e\u306emiRNA\u304c\u6e1b\u5c11\u3057\u305f\u306e\u3092\u8e0f\u307e\u3048\u3001\u4eba\u5de5\u7684\u306b\u4f5c\u88fd\u3057\u305fmiRNA-141-3p\u3068miRNA-200a-3p\u3092\u03b1-MSH\u3067\u523a\u6fc0\u5f8c\u306e\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u6291\u5236\u3055\u308c\u308b\u306e\u304b\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001miRNA-141-3p\u3068miRNA-200a-3p\u306e\u5c0e\u5165\u306b\u3088\u308a\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n![\"\u56f33\"](\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2020\/03\/c8856789ec11ab8b1013037cef6929f9-1.png\")
<\/p>\n
\n\u203bArbutin:\u30b3\u30b1\u30e2\u30e2\u3084\u30a6\u30ef\u30a6\u30eb\u30b7\u3001\u30ca\u30b7\u306a\u3069\u306e\u690d\u7269\u306e\u8449\u306b\u542b\u307e\u308c\u308b\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u914d\u7cd6\u4f53\u3002\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u5f8b\u901f\u9175\u7d20\u3067\u3042\u308b\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u7f8e\u767d\u4f5c\u7528\u3092\u793a\u3057\u3001\u7f8e\u767d\u7528\u533b\u85ac\u90e8\u5916\u54c1\u4e3b\u5264\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n
\n\u3000<\/strong>\u30d2\u30c8\u306e\u76ae\u819a\u3092\u6a21\u5023\u3057\u305f\uff13\u6b21\u5143\u30d2\u30c8\u76ae\u819a\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3057\u3066\u3001miRNA-141-3p\u3068miRNA-200a-3p\u306b\u3088\u308a\u3001\u03b1-MSH\u3067\u523a\u6fc0\u5f8c\u306e\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u6291\u5236\u3055\u308c\u308b\u304b\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u30ea\u30dd\u30bd\u30fc\u30e0 \u203b6<\/sup><\/span>\u306b\u3088\u308amiRNA-141-3p\u3068miRNA-200a-3p\u3092\u305d\u308c\u305e\u308c\u76ae\u819a\u30e2\u30c7\u30eb\u306b\u5c0e\u5165\u3057\u3001\u03b1-MSH\u3067\u523a\u6fc0\u3057\u305f\u57f9\u5730\u3067\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u4fc3\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\uff13\u6b21\u5143\u30d2\u30c8\u76ae\u819a\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3082\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001miRNA-141-3p\u3068miRNA-200a-3p\u306b\u3088\u308a\u808c\u7d30\u80de\u306b\u304a\u3051\u308b\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u6291\u5236\u3055\u308c\u3001\u3053\u308c\u3089\u306emiRNA\u306e\u6d3b\u7528\u306b\u3088\u308b\u5316\u7ca7\u54c1\u958b\u767a\u306e\u53ef\u80fd\u6027\u304c\u671f\u5f85\u3055\u308c\u308b\u7d50\u679c\u3068\u306a\u308a\u307e\u3059\u3002
\n\u203b6\u3000\u7d30\u80de\u5185\u306b\u6210\u5206\u306a\u3069\u3092\u5c0e\u5165\u3059\u308b\u5b9f\u9a13\u306b\u5229\u7528\u3055\u308c\u308b\u7403\u5f62\u306e\u5c0f\u80de\u3002<\/span><\/p>\n![\"\u56f34\"](\"https:\/\/www.euglena.jp\/wp_01\/wp-content\/uploads\/2020\/03\/3a4f695a458cb0ac0aceaa2eb13ac2dd-1.png\")
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