サルファーインデックス受託分析サービス

サルファーインデックス受託分析サービス

Sulfur Index Research

Introduction Research

Comprehensive measurement and analysis of sulfur compounds

サルファーインデックス技術は、硫黄化合物に特異的な誘導体化試薬を用いたLC-MS/MSを実施することにより、一般的な手法では検出できない微量な硫黄化合物の高感度かつ網羅的な検出や、有機硫黄化合物、無機硫黄化合物、さらには酸化型、還元型を問わず約50種類の硫黄化合物を同時に分析することができる技術です。生体試料や食品、培養プロセスにおける酸化還元状態や代謝物量を把握し、生命現象の新規なメカニズムの発見、製造プロセスの改良に貢献します。

Why sulfur

Sulfur circulates globally

Just as there is a carbon cycle and a nitrogen cycle, so does sulfur.

The strengths and weaknesses of sulfur metabolism are clear depending on the organism, and especially the microorganisms that are good at "assimilation" that converts inorganic sulfur compounds into organic sulfur compounds are limited.
Many microorganisms and plants (crops) are not good at assimilating sulfur compounds, and animals including humans do not have the ability to assimilate sulfur compounds.

In other words, by comprehensively analyzing sulfur compounds, it is possible to understand the living environment and growing environment of what kind of foods people and crops were ingested and in what kind of environment they grew up.

Sulfur gives you a bird's eye view of your entire metabolism

The sulfur metabolism system exists in close proximity to the central metabolism system consisting of glycolysis and the TCA cycle. The glycolysis system and the TCA cycle are connected to the nucleic acid metabolism system and the amino acid metabolism system, respectively, and are mutually balanced for the survival of living organisms.

The Sulfur Index Service not only analyzes sulfur, but also considers the situation of nitrogen and carbon metabolism by grasping sulfur metabolism, and as the next step, it focuses on the central metabolism system, nucleic acid metabolism system, etc. Focused metabolome Verify with analysis and come up with the final answer.
Sulfur metabolism has the advantage that it requires a small number of compounds to analyze and is relatively easy to consider.

Sulfur modifies various proteins

The cysteine thiol group of a protein is a very important functional group for exerting functionality such as the formation of its three-dimensional structure. The cysteine thiol group is chemically modified by active oxygen and nitric oxide to become sulfenic acid, S-nitrosyl, and disulfide, and its functionality changes. Sulfur enhances or suppresses its activity by sulfhydrylating those chemically modified parts.

Past achievements

It is already used in many fields.

Application example 1 (Food) Food: Quality control, process control
  • ● Quality control
    By using sulfur index technology, it is possible to check whether foods are manufactured with the same quality. In addition, by applying this, it is possible to convey to consumers the differences from other companies' products in an easy-to-understand manner.
  • ● Process management
    Sulfur index technology is useful for controlling the manufacturing process of fermented foods (liquor, miso, soy sauce, etc.) that use microorganisms. Sulfur compounds are produced during the activity of the microbial fermentation process and therefore reflect the state of the fermentation process.
Application example 2 (medicine) Health / Medical: Disease marker search, cell culture management
  • ● Search for disease markers
    Sulfur index technology is useful as an index for searching for disease markers because sulfur metabolites are deeply involved in the regulation of physiological functions. In particular, since the cost per sample can be kept low, it is possible to compare and analyze multiple samples even within a limited budget. Blood, urine, saliva and feces can all be analyzed.
  • ● Cell culture management
    Sulfur compounds (methionine and SAM) are deeply involved in maintaining the proliferation and differentiation potential of pluripotent stem cells. In addition, since CHO cells, which are cells that produce antibody drugs, require a large amount of cysteine, the sulfur index technology is useful as an index for cell culture management.
Application example 3 (Agriculture) Soil and environmental sample analysis, quality evaluation of agricultural products
  • ● Soil analysis
    Soil is generally evaluated by physical, chemical, and biological properties, but the method of evaluating biological properties is expensive, and there are cases where it cannot be applied to actual agriculture or information is extremely limited. Mostly. Sulfur index technology can be used to comprehensively evaluate the microbial state of soil from the perspective of sulfur metabolism.
  • ● Quality evaluation
    Crops have sulfur metabolism as one life form. By analyzing the sulfur metabolism with the sulfur index technology, it is possible to characterize the target vegetables based on indicators that approach the essence of the crop, which are different from the fragmentary taste such as sweetness and bitterness, size and weight. Is possible.

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